Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2021 Oct 23

PMID 34682364

Citations 1

Authors

Ting Zhu

Yuxiang Hu

Jooyeon Hwang

Dan Zhao

Libin Huang

Liang Qiao

Ankui Wei

Xin Xu

Affiliations

Soon will be listed here.

Abstract

Firefighting rescues are high-hazard activities accompanied by uncertainty, urgency, and complexity. Knowledge of the metabolic characteristics during firefighting rescues is of great value. The purpose of this study was to explore the firefighting-induced physiological responses in greater depth. The urine samples of ten firefighters were collected before and after the simulated firefighting, and the proteins in urine samples were identified by the liquid chromatography-mass spectroscopy. Blood lactate and heart rate were measured. There were 360 proteins up-regulated and 265 proteins downregulated after this simulated firefighting. Changes in protein expression were significantly related to acute inflammatory responses, immune responses, complement activation, and oxidative stress. Beta-2-microglobulin (r = 0.76, < 0.05) and von Willebrand factors (r = 0.81, < 0.01) were positively correlated with heart rate during simulated firefighting, and carbonic anhydrase 1 (r = 0.67, < 0.05) were positively correlated with blood lactate after simulated firefighting. These results illustrated that Beta-2-microglobulin, von Willebrand, and carbonic anhydrase 1 could be regarded as important indicators to evaluate exercise intensity for firefighters.

Citing Articles

The expression of glycolysis-related proteins in urine significantly increases after running.

Zhao T, Liu T, Li T, Chen S, Wang L, Zhang M Front Physiol. 2024; 15:1481741.

PMID: 39717827 PMC: 11663847. DOI: 10.3389/fphys.2024.1481741.

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