Controlled Release of Doxorubicin for Targeted Chemo-Photothermal Therapy in Breast Cancer HS578T Cells Using Albumin Modified Hybrid Nanocarriers

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Oct 23

PMID 34681890

Citations 4

Authors

Barbara Carrese

Chiara Cavallini

Gennaro Sanita

Paolo Armanetti

Brigida Silvestri

Gaetano Cali

Giulio Pota

Giuseppina Luciani

Luca Menichetti

Annalisa Lamberti

Affiliations

Soon will be listed here.

Abstract

Hybrid nanomaterials have attracted research interest owing to their intriguing properties, which may offer new diagnostic options with triggering features, able to realize a new kind of tunable nanotherapeutics. Hybrid silica/melanin nanoparticles (NPs) containing silver seeds (Me-laSil_Ag-HSA NPs) disclosed relevant photoacoustic contrast for molecular imaging. In this study we explored therapeutic function in the same nanoplatform. For this purpose, MelaSil_Ag-HSA were loaded with doxorubicin (DOX) (MelaSil_Ag-HSA@DOX) and tested to assess the efficiency of drug delivery combined with concurrent photothermal treatment. The excellent photothermal properties allowed enhanced cytotoxic activity at significantly lower doses than neat chemotherapeutic treatment. The results revealed that MelaSil_Ag-HSA@DOX is a promising platform for an integrated photothermal (PT) chemotherapy approach, reducing the efficacy concentration of the DOX and, thus, potentially limiting the several adverse side effects of the drug in in vivo treatments.

Citing Articles

Hybrid Nanoparticle-Assisted Chemo-Photothermal Therapy and Photoacoustic Imaging in a Three-Dimensional Breast Cancer Cell Model.

Carrese B, Cavallini C, Armanetti P, Silvestri B, Cali G, Luciani G Int J Mol Sci. 2023; 24(24).

PMID: 38139203 PMC: 10743567. DOI: 10.3390/ijms242417374.

Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures.

Venuta A, Nasso R, Gisonna A, Iuliano R, Montesarchio S, Acampora V Life (Basel). 2023; 13(4).

PMID: 37109596 PMC: 10141119. DOI: 10.3390/life13041067.

Nanostrategies: The Future Medicine for Fighting Cancer Progression and Drug Resistance 2.0.

Beretta G Int J Mol Sci. 2022; 23(22).

PMID: 36430963 PMC: 9695259. DOI: 10.3390/ijms232214486.

Nanoparticles Design for Theranostic Approach in Cancer Disease.

Carrese B, Sanita G, Lamberti A Cancers (Basel). 2022; 14(19).

PMID: 36230578 PMC: 9564040. DOI: 10.3390/cancers14194654.

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