Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Oct 23

PMID 34681856

Citations 8

Authors

Christodoula Kourtidou

Maria Stangou

Smaragdi Marinaki

Konstantinos Tziomalos

Affiliations

Soon will be listed here.

Abstract

Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factors that underpin the association between DKD and cardiovascular disease (CVD) is essential for risk stratification, for individualization of treatment and for identification of novel treatment targets.In the present review, we summarize the current knowledge regarding the role of emerging cardiovascular risk markers in patients with DKD. Among these biomarkers, fibroblast growth factor-23 and copeptin were studied more extensively and consistently predicted cardiovascular events in this population. Therefore, it might be useful to incorporate them in risk stratification strategies in patients with DKD to identify those who would possibly benefit from more aggressive management of cardiovascular risk factors.

Citing Articles

Interrelation of Natural Polyphenol and Fibrosis in Diabetic Nephropathy.

Ma Y, Wang J, Fan J, Jia H, Li J Molecules. 2025; 30(1).

PMID: 39795078 PMC: 11722366. DOI: 10.3390/molecules30010020.

Residual Syntax score and percutaneous coronary intervention in diabetic patients with renal insufficiency.

Peng M, Ye T, Lan K, Xiong B, Xia L, Ding X Am J Transl Res. 2024; 16(10):5909-5922.

PMID: 39544740 PMC: 11558376. DOI: 10.62347/VGPJ3431.

Predictive Effects of FT3/FT4 on Diabetic Kidney Disease: An Exploratory Study on Hospitalized Euthyroid Patients with T2DM in China.

Zhao X, Sun J, Xin S, Zhang X Biomedicines. 2023; 11(8).

PMID: 37626708 PMC: 10452238. DOI: 10.3390/biomedicines11082211.

Effects of arteriovenous fistulas and central venous catheters on the cardiac function and prognosis of patients on maintenance hemodialysis.

He X, Liu Y Pak J Med Sci. 2023; 39(3):780-784.

PMID: 37250573 PMC: 10214819. DOI: 10.12669/pjms.39.3.7151.

Biocompatible Macroion/Growth Factor Assemblies for Medical Applications.

Michna A, Pomorska A, Ozcan O Biomolecules. 2023; 13(4).

PMID: 37189357 PMC: 10136312. DOI: 10.3390/biom13040609.

References

Han W, Bailly V, Abichandani R, Thadhani R, Bonventre J . Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 2002; 62(1):237-44. DOI: 10.1046/j.1523-1755.2002.00433.x. View

Schmidt I, Srivastava A, Sabbisetti V, McMahon G, He J, Chen J . Plasma Kidney Injury Molecule 1 in CKD: Findings From the Boston Kidney Biopsy Cohort and CRIC Studies. Am J Kidney Dis. 2021; 79(2):231-243.e1. PMC: 8709877. DOI: 10.1053/j.ajkd.2021.05.013. View

Buraczynska M, Dragan M, Buraczynska K, Orlowska-Kowalik G, Ksiazek A . Matrix metalloproteinase-2 (MMP-2) gene polymorphism and cardiovascular comorbidity in type 2 diabetes patients. J Diabetes Complications. 2015; 29(6):829-33. DOI: 10.1016/j.jdiacomp.2015.05.004. View

Bardoux P, Martin H, Ahloulay M, Schmitt F, Bouby N, Trinh-Trang-Tan M . Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: study in vasopressin-deficient Brattleboro rats. Proc Natl Acad Sci U S A. 1999; 96(18):10397-402. PMC: 17899. DOI: 10.1073/pnas.96.18.10397. View

Khan F, Fatima S, Khan G, Shahid S . Evaluation of kidney injury molecule-1 as a disease progression biomarker in diabetic nephropathy. Pak J Med Sci. 2019; 35(4):992-996. PMC: 6659046. DOI: 10.12669/pjms.35.4.154. View

El Boustany R . Vasopressin and Diabetic Kidney Disease. Ann Nutr Metab. 2018; 72 Suppl 2:17-20. DOI: 10.1159/000488124. View

Noor T, Hanif F, Kiran Z, Rehman R, Khan M, Haque Z . Relation of Copeptin with Diabetic and Renal Function Markers Among Patients with Diabetes Mellitus Progressing Towards Diabetic Nephropathy. Arch Med Res. 2020; 51(6):548-555. DOI: 10.1016/j.arcmed.2020.05.018. View

de Carvalho J, Tatsch E, Hausen B, Bollick Y, Moretto M, Duarte T . Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as indicators of tubular damage in normoalbuminuric patients with type 2 diabetes. Clin Biochem. 2015; 49(3):232-6. DOI: 10.1016/j.clinbiochem.2015.10.016. View

Xu H, Cheng Y, Wang W, Wu H, Zhang Y, Zang C . 12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance. Int J Mol Sci. 2016; 17(5). PMC: 4881510. DOI: 10.3390/ijms17050684. View

10.

El-Saeed A, El-Mohasseb G . Circulating Fibroblast Growth Factors 21 and 23 as Biomarkers of Progression in Diabetic Nephropathy in Type 2 Diabetes with Normoalbuminuria. Egypt J Immunol. 2018; 24(2):93-99. View

11.

Zhang L, Liu T . Clinical implication of alterations in serum Klotho levels in patients with type 2 diabetes mellitus and its associated complications. J Diabetes Complications. 2018; 32(10):922-930. DOI: 10.1016/j.jdiacomp.2018.06.002. View

12.

Bob F, Schiller A, Timar R, Lighezan D, Schiller O, Timar B . Rapid decline of kidney function in diabetic kidney disease is associated with high soluble Klotho levels. Nefrologia (Engl Ed). 2018; 39(3):250-257. DOI: 10.1016/j.nefro.2018.08.004. View

13.

Bjornstad P, Maahs D, Jensen T, Lanaspa M, Johnson R, Rewers M . Elevated copeptin is associated with atherosclerosis and diabetic kidney disease in adults with type 1 diabetes. J Diabetes Complications. 2016; 30(6):1093-6. PMC: 4949105. DOI: 10.1016/j.jdiacomp.2016.04.012. View

14.

Peeters S, Engelen L, Buijs J, Chaturvedi N, Fuller J, Jorsal A . Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies. Cardiovasc Diabetol. 2017; 16(1):139. PMC: 5657128. DOI: 10.1186/s12933-017-0620-9. View

15.

Carlsson A, Nowak C, Lind L, Ostgren C, Nystrom F, Sundstrom J . Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach. Ups J Med Sci. 2019; 125(1):37-43. PMC: 7054929. DOI: 10.1080/03009734.2019.1696430. View

16.

Najafi L, Rajabi S, Pirsaheb S, Keyvani H, Khajavi A, Shati M . Assessment of Serum and Urine Neurophil Gelatinase- Associated Lipocalin (s-NGAL and u-NGAL) Level as a Predictive Factor of Disease Progression in Diabetic Nephropathy in Type 2 DM. Iran J Kidney Dis. 2021; 15(4):270-278. View

17.

Zhu F, Wu H, Tu K, Chen J, Zhang M, Shi C . Serum levels of copeptin are associated with type 2 diabetes and diabetic complications in Chinese population. J Diabetes Complications. 2016; 30(8):1566-1570. DOI: 10.1016/j.jdiacomp.2016.07.017. View

18.

Velho G, El Boustany R, Lefevre G, Mohammedi K, Fumeron F, Potier L . Plasma Copeptin, Kidney Outcomes, Ischemic Heart Disease, and All-Cause Mortality in People With Long-standing Type 1 Diabetes. Diabetes Care. 2016; 39(12):2288-2295. DOI: 10.2337/dc16-1003. View

19.

Garcia-Tejeda A, Sampieri C, Suarez-Torres I, Morales-Romero J, Demeneghi-Marini V, Hernandez-Hernandez M . Association of urinary activity of MMP-9 with renal impairment in Mexican patients with type 2 diabetes mellitus. PeerJ. 2018; 6:e6067. PMC: 6286807. DOI: 10.7717/peerj.6067. View

20.

Vaduganathan M, White W, Charytan D, Morrow D, Liu Y, Zannad F . Relation of Serum and Urine Renal Biomarkers to Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus and Recent Acute Coronary Syndromes (From the EXAMINE Trial). Am J Cardiol. 2018; 123(3):382-391. DOI: 10.1016/j.amjcard.2018.10.035. View