Disease Modeling of Mitochondrial Cardiomyopathy Using Patient-Specific Induced Pluripotent Stem Cells

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2021 Oct 23

PMID 34681080

Citations 3

Authors

Takeshi Tokuyama

Razan Elfadil Ahmed

Nawin Chanthra

Tatsuya Anzai

Hideki Uosaki

Affiliations

Soon will be listed here.

Abstract

Mitochondrial cardiomyopathy (MCM) is characterized as an oxidative phosphorylation disorder of the heart. More than 100 genetic variants in nuclear or mitochondrial DNA have been associated with MCM. However, the underlying molecular mechanisms linking genetic variants to MCM are not fully understood due to the lack of appropriate cellular and animal models. Patient-specific induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs) provide an attractive experimental platform for modeling cardiovascular diseases and predicting drug efficacy to such diseases. Here we introduce the pathological and therapeutic studies of MCM using iPSC-CMs and discuss the questions and latest strategies for research using iPSC-CMs.

Citing Articles

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