Different Inhibitory Effects of Erythromycin and Chlortetracycline on Early Growth of Seedlings

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Oct 23

PMID 34680853

Authors

Mi Sun Cheong

Hyeonji Choe

Myeong Seon Jeong

Young-Eun Yoon

Hyun Suk Jung

Yong Bok Lee

Affiliations

Soon will be listed here.

Abstract

Veterinary antibiotics, including erythromycin (Ery) and chlortetracycline (CTC), are often detected in agricultural land. Although these contaminants affect plant growth and development, their effects on crops remain elusive. In this study, the effects of Ery and CTC on plant growth were investigated and compared by analyzing transcript abundance in seedlings. Treatment with Ery and/or CTC reduced chlorophyll content in leaves and photosynthetic efficiency. Examination of the chloroplast ultrastructure revealed the presence of abnormally shaped plastids in response to Ery and CTC treatments. The antibiotics produced similar phenotypes of lower accumulation of photosynthetic genes, including and . Analysis of the transcript levels revealed that Ery and CTC differentially down-regulated genes involved in the tetrapyrrole biosynthetic pathway and primary root growth. In the presence of Ery and CTC, chloroplasts were undeveloped and photosynthesis efficiency was reduced. These results suggest that both Ery and CTC individually affect gene expression and influence plant physiological activity, independently of one another.

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