Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Oct 23

PMID 34680797

Citations 8

Authors

Sabine Pereyre

Florence Tardy

Affiliations

Soon will be listed here.

Abstract

Mycoplasma infections are frequent in humans, as well as in a broad range of animals. However, antimicrobial treatment options are limited, partly due to the lack of a cell wall in these peculiar bacteria. Both veterinary and human medicines are facing increasing resistance prevalence for the most commonly used drugs, despite different usage practices. To date, very few reviews have integrated knowledge on resistance to antimicrobials in humans and animals, the latest dating back to 2014. To fill this gap, we examined, in parallel, antimicrobial usage, resistance mechanisms and either phenotype or genotype-based methods for antimicrobial susceptibility testing, as well as epidemiology of resistance of the most clinically relevant human and animal mycoplasma species. This review unveiled common features and differences that need to be taken into consideration in a "One Health" perspective. Lastly, two examples of critical cases of multiple drug resistance are highlighted, namely, the human and the animal species, both of which can lead to the threat of untreatable infections.

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References

Watanabe M, Hitomi S, Goto M, Hasegawa Y . Bloodstream infection due to Mycoplasma arginini in an immunocompromised patient. J Clin Microbiol. 2012; 50(9):3133-5. PMC: 3421792. DOI: 10.1128/JCM.00736-12. View

Neimark H, Hoff B, Ganter M . Mycoplasma ovis comb. nov. (formerly Eperythrozoon ovis), an epierythrocytic agent of haemolytic anaemia in sheep and goats. Int J Syst Evol Microbiol. 2004; 54(Pt 2):365-371. DOI: 10.1099/ijs.0.02858-0. View

Sweeney M, Lubbers B, Schwarz S, Watts J . Applying definitions for multidrug resistance, extensive drug resistance and pandrug resistance to clinically significant livestock and companion animal bacterial pathogens. J Antimicrob Chemother. 2018; 73(6):1460-1463. DOI: 10.1093/jac/dky043. View

Godinho K, Rae A, Windsor G, Tilt N, Rowan T, Sunderland S . Efficacy of tulathromycin in the treatment of bovine respiratory disease associated with induced Mycoplasma bovis infections in young dairy calves. Vet Ther. 2005; 6(2):96-112. View

White C, Jewer D . Seal finger: A case report and review of the literature. Can J Plast Surg. 2010; 17(4):133-5. PMC: 2827281. DOI: 10.1177/229255030901700415. View

Ducours M, Alleman L, Puges M, Deborde M, Hessamfar M, Le-Marec F . Incidence of sexually transmitted infections during pre-exposure prophylaxis for HIV: a worrying outcome at 2 years!. Sex Transm Infect. 2019; 95(7):552. DOI: 10.1136/sextrans-2019-054070. View

KENNY G, Cartwright F . Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their.... Antimicrob Agents Chemother. 2001; 45(9):2604-8. PMC: 90699. DOI: 10.1128/AAC.45.9.2604-2608.2001. View

Li Y, Su X, Le W, Li S, Yang Z, Chaisson C . Mycoplasma genitalium in Symptomatic Male Urethritis: Macrolide Use Is Associated With Increased Resistance. Clin Infect Dis. 2019; 70(5):805-810. PMC: 7390511. DOI: 10.1093/cid/ciz294. View

Cazanave C, Manhart L, Bebear C . Mycoplasma genitalium, an emerging sexually transmitted pathogen. Med Mal Infect. 2012; 42(9):381-92. DOI: 10.1016/j.medmal.2012.05.006. View

10.

Khalil D, Becker C, Tardy F . Alterations in the Quinolone Resistance-Determining Regions and Fluoroquinolone Resistance in Clinical Isolates and Laboratory-Derived Mutants of Mycoplasma bovis: Not All Genotypes May Be Equal. Appl Environ Microbiol. 2015; 82(4):1060-1068. PMC: 4751855. DOI: 10.1128/AEM.03280-15. View

11.

Proctor R, Kriegeskorte A, Kahl B, Becker K, Loffler B, Peters G . Staphylococcus aureus Small Colony Variants (SCVs): a road map for the metabolic pathways involved in persistent infections. Front Cell Infect Microbiol. 2014; 4:99. PMC: 4112797. DOI: 10.3389/fcimb.2014.00099. View

12.

Falk L, Jensen J . Successful outcome of macrolide-resistant Mycoplasma genitalium urethritis after spectinomycin treatment: a case report. J Antimicrob Chemother. 2016; 72(2):624-625. DOI: 10.1093/jac/dkw405. View

13.

Durukan D, Doyle M, Murray G, Bodiyabadu K, Vodstrcil L, Chow E . Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium. Emerg Infect Dis. 2020; 26(8):1870-1874. PMC: 7392426. DOI: 10.3201/eid2608.191806. View

14.

Jensen J, Norgaard C, Scangarella-Oman N, Unemo M . activity of the first-in-class triazaacenaphthylene gepotidacin alone and in combination with doxycycline against drug-resistant and -susceptible . Emerg Microbes Infect. 2020; 9(1):1388-1392. PMC: 7473033. DOI: 10.1080/22221751.2020.1775498. View

15.

Dumke R, Ziegler T . Long-Term Low Rate of Macrolide-Resistant Strains in Germany. Antimicrob Agents Chemother. 2019; 63(5). PMC: 6496069. DOI: 10.1128/AAC.00455-19. View

16.

Bercot B, Charreau I, Rousseau C, Delaugerre C, Chidiac C, Pialoux G . High Prevalence and High Rate of Antibiotic Resistance of Mycoplasma genitalium Infections in Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Pre-exposure Prophylaxis Trial. Clin Infect Dis. 2020; 73(7):e2127-e2133. DOI: 10.1093/cid/ciaa1832. View

17.

Gautier-Bouchardon A . Antimicrobial Resistance in spp. Microbiol Spectr. 2018; 6(4). PMC: 11633602. DOI: 10.1128/microbiolspec.ARBA-0030-2018. View

18.

Kenri T, Suzuki M, Sekizuka T, Ohya H, Oda Y, Yamazaki T . Periodic Genotype Shifts in Clinically Prevalent Strains in Japan. Front Cell Infect Microbiol. 2020; 10:385. PMC: 7424021. DOI: 10.3389/fcimb.2020.00385. View

19.

Le Roy C, Bebear C, Pereyre S . Performance of Three Commercial Molecular Diagnostic Assays for the Simultaneous Detection of Mycoplasma genitalium and Macrolide Resistance. J Clin Microbiol. 2021; 59(6). PMC: 8316089. DOI: 10.1128/JCM.00020-21. View

20.

Touati A, Peuchant O, Jensen J, Bebear C, Pereyre S . Direct detection of macrolide resistance in Mycoplasma genitalium isolates from clinical specimens from France by use of real-time PCR and melting curve analysis. J Clin Microbiol. 2014; 52(5):1549-55. PMC: 3993663. DOI: 10.1128/JCM.03318-13. View