Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials
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Mycoplasma infections are frequent in humans, as well as in a broad range of animals. However, antimicrobial treatment options are limited, partly due to the lack of a cell wall in these peculiar bacteria. Both veterinary and human medicines are facing increasing resistance prevalence for the most commonly used drugs, despite different usage practices. To date, very few reviews have integrated knowledge on resistance to antimicrobials in humans and animals, the latest dating back to 2014. To fill this gap, we examined, in parallel, antimicrobial usage, resistance mechanisms and either phenotype or genotype-based methods for antimicrobial susceptibility testing, as well as epidemiology of resistance of the most clinically relevant human and animal mycoplasma species. This review unveiled common features and differences that need to be taken into consideration in a "One Health" perspective. Lastly, two examples of critical cases of multiple drug resistance are highlighted, namely, the human and the animal species, both of which can lead to the threat of untreatable infections.
Wang Q, Ruan Z, Wang Y, Zhang Y, Chai X Fish Physiol Biochem. 2025; 51(2):54.
PMID: 39994088 DOI: 10.1007/s10695-025-01450-w.
Popov I, Popov I, Chebotareva I, Tikhmeneva I, Peshkova D, Krikunova A Braz J Microbiol. 2025; .
PMID: 39961999 DOI: 10.1007/s42770-025-01630-z.
Zhu L, Shen W, Zou X, Zuo J, Xiao N Front Med (Lausanne). 2025; 12:1510753.
PMID: 39931564 PMC: 11807816. DOI: 10.3389/fmed.2025.1510753.
: not a typical respiratory pathogen.
Rowlands R, Meyer Sauteur P, Beeton M, The Escmid Study Group For Mycoplasma And Chlamydia Infections Esgmac J Med Microbiol. 2024; 73(10).
PMID: 39475213 PMC: 11523975. DOI: 10.1099/jmm.0.001910.
Mate L, Alvarez L, Lloberas M, Imperiale F, Lanusse C, Liron J PLoS One. 2024; 19(6):e0306390.
PMID: 38935803 PMC: 11210874. DOI: 10.1371/journal.pone.0306390.