Telomere Length and Regulatory Genes As Novel Stress Biomarkers and Their Diversities in Broiler Chickens () Subjected to Corticosterone Feeding

Overview

Journal Animals (Basel)

Date 2021 Oct 23

PMID 34679783

Citations 6

Authors

Kazeem Ajasa Badmus

Zulkifli Idrus

Goh Yong Meng

Awis Qurni Sazili

Kamalludin Mamat-Hamidi

Affiliations

Soon will be listed here.

Abstract

This study was designed to characterize telomere length and its regulatory genes and to evaluate their potential as well-being biomarkers. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and performances, organ weight, plasma CORT levels, telomere lengths and regulatory genes were measured and recorded. Body weights of CORT-fed chickens were significantly suppressed ( < 0.05), and organ weights and circulating CORT plasma levels ( < 0.05) were altered. Interaction effect of CORT and duration was significant ( < 0.05) on heart and liver telomere length. CORT significantly ( < 0.05) shortened the telomere length of the whole blood, muscle, liver and heart. The , and were significantly ( < 0.05) upregulated in the liver and heart at week 4 although these genes and were downregulated in the muscles at weeks 2 and 4. Therefore, telomere lengths and their regulators are associated and diverse, so they can be used as novel biomarkers of stress in broiler chickens fed with CORT.

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References

Dhabhar F, McEwen B . Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: a potential role for leukocyte trafficking. Brain Behav Immun. 1998; 11(4):286-306. DOI: 10.1006/brbi.1997.0508. View

Monaghan P . Telomeres and life histories: the long and the short of it. Ann N Y Acad Sci. 2010; 1206:130-42. DOI: 10.1111/j.1749-6632.2010.05705.x. View

Barna J, Csermely P, Vellai T . Roles of heat shock factor 1 beyond the heat shock response. Cell Mol Life Sci. 2018; 75(16):2897-2916. PMC: 11105406. DOI: 10.1007/s00018-018-2836-6. View

Blackburn E . Structure and function of telomeres. Nature. 1991; 350(6319):569-73. DOI: 10.1038/350569a0. View

von Zglinicki T . Oxidative stress shortens telomeres. Trends Biochem Sci. 2002; 27(7):339-44. DOI: 10.1016/s0968-0004(02)02110-2. View

Goichberg P, Chang J, Liao R, Leri A . Cardiac stem cells: biology and clinical applications. Antioxid Redox Signal. 2014; 21(14):2002-17. PMC: 4208604. DOI: 10.1089/ars.2014.5875. View

Scheibe M, Arnoult N, Kappei D, Buchholz F, Decottignies A, Butter F . Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators. Genome Res. 2013; 23(12):2149-57. PMC: 3847783. DOI: 10.1101/gr.151878.112. View

Armanios M . Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest. 2013; 123(3):996-1002. PMC: 3673231. DOI: 10.1172/JCI66370. View

Strong M, Vidal-Cardenas S, Karim B, Yu H, Guo N, Greider C . Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase. Mol Cell Biol. 2011; 31(12):2369-79. PMC: 3133422. DOI: 10.1128/MCB.05312-11. View

10.

Epel E, Blackburn E, Lin J, Dhabhar F, Adler N, Morrow J . Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004; 101(49):17312-5. PMC: 534658. DOI: 10.1073/pnas.0407162101. View

11.

Whittemore K, Vera E, Martinez-Nevado E, Sanpera C, Blasco M . Telomere shortening rate predicts species life span. Proc Natl Acad Sci U S A. 2019; 116(30):15122-15127. PMC: 6660761. DOI: 10.1073/pnas.1902452116. View

12.

Cusanelli E, Perez Romero C, Chartrand P . Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres. Mol Cell. 2013; 51(6):780-91. DOI: 10.1016/j.molcel.2013.08.029. View

13.

Yip B, Mok H, Peterson D, Wan M, Taniguchi Y, Ge W . Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging. Mar Pollut Bull. 2017; 124(2):701-709. DOI: 10.1016/j.marpolbul.2017.01.021. View

14.

Lin H, Sui S, Jiao H, Buyse J, Decuypere E . Impaired development of broiler chickens by stress mimicked by corticosterone exposure. Comp Biochem Physiol A Mol Integr Physiol. 2006; 143(3):400-5. DOI: 10.1016/j.cbpa.2005.12.030. View

15.

Spiers J, Chen H, Sernia C, Lavidis N . Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress. Front Neurosci. 2015; 8:456. PMC: 4298223. DOI: 10.3389/fnins.2014.00456. View

16.

Okamoto K, Iwano T, Tachibana M, Shinkai Y . Distinct roles of TRF1 in the regulation of telomere structure and lengthening. J Biol Chem. 2008; 283(35):23981-8. PMC: 3259774. DOI: 10.1074/jbc.M802395200. View

17.

Blackburn E, Chan S, Chang J, Fulton T, Krauskopf A, McEachern M . Molecular manifestations and molecular determinants of telomere capping. Cold Spring Harb Symp Quant Biol. 2003; 65:253-63. DOI: 10.1101/sqb.2000.65.253. View

18.

Blackburn E . Switching and signaling at the telomere. Cell. 2001; 106(6):661-73. DOI: 10.1016/s0092-8674(01)00492-5. View

19.

Greider C, Blackburn E . Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 1985; 43(2 Pt 1):405-13. DOI: 10.1016/0092-8674(85)90170-9. View

20.

DUNHAM M, Neumann A, Fasching C, Reddel R . Telomere maintenance by recombination in human cells. Nat Genet. 2000; 26(4):447-50. DOI: 10.1038/82586. View