Sleep-Related Rhythmic Movement Disorder in Young Children with Down Syndrome: Prevalence and Clinical Features

Overview

Journal Brain Sci

Publisher MDPI

Date 2021 Oct 23

PMID 34679391

Citations 3

Authors

Ceren Kose

Izabelle Wood

Amy Gwyther

Susiksha Basnet

Chloe Gaskell

Paul Gringras

Heather Elphick

Hazel Evans

Catherine M Hill

Affiliations

Soon will be listed here.

Abstract

Sleep-related Rhythmic Movement Disorder (RMD) affects around 1% of UK pre-school children. Little is known about RMD in Down syndrome (DS). We aimed to determine: (a) the prevalence of RMD in children with DS aged 1.5-8 years; (b) phenotypic and sleep quality differences between children with DS and RMD and sex- and age-matched DS controls; and (c) night-to-night variability in rhythmic movements (RMs). Parents who previously reported RMs from a DS research registry of 202 children were contacted. If clinical history suggested RMD, home videosomnography (3 nights) was used to confirm RMs and actigraphy (5 nights) was used to assess sleep quality. Phenotype was explored by demographic, strengths and difficulties, Q-CHAT-10/social communication and life events questionnaires. Eight children had confirmed RMD. Minimal and estimated maximal prevalence were 4.10% and 15.38%, respectively. Sleep efficiency was significantly lower in RMD-cases (69.1%) versus controls (85.2%), but there were no other phenotypic differences. There was considerable intra-individual night-to-night variability in RMs. In conclusion, RMD has a high prevalence in children with DS, varies from night to night and is associated with poor sleep quality but, in this small sample, no daytime phenotypic differences were found compared to controls. Children with DS should be screened for RMD, which is amenable to treatment.

Citing Articles

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References

Levanon A, Tarasiuk A, Tal A . Sleep characteristics in children with Down syndrome. J Pediatr. 1999; 134(6):755-60. DOI: 10.1016/s0022-3476(99)70293-3. View

Joyce A, Elphick H, Farquhar M, Gringras P, Evans H, Bucks R . Obstructive Sleep Apnoea Contributes to Executive Function Impairment in Young Children with Down Syndrome. Behav Sleep Med. 2019; 18(5):611-621. DOI: 10.1080/15402002.2019.1641501. View

Carter M, McCaughey E, Annaz D, Hill C . Sleep problems in a Down syndrome population. Arch Dis Child. 2008; 94(4):308-10. DOI: 10.1136/adc.2008.146845. View

Hill C, Evans H, Elphick H, Farquhar M, Pickering R, Kingshott R . Prevalence and predictors of obstructive sleep apnoea in young children with Down syndrome. Sleep Med. 2016; 27-28:99-106. DOI: 10.1016/j.sleep.2016.10.001. View

Sallustro F, Atwell C . Body rocking, head banging, and head rolling in normal children. J Pediatr. 1978; 93(4):704-8. DOI: 10.1016/s0022-3476(78)80922-6. View

Gogo E, van Sluijs R, Cheung T, Gaskell C, Jones L, Alwan N . Objectively confirmed prevalence of sleep-related rhythmic movement disorder in pre-school children. Sleep Med. 2018; 53:16-21. DOI: 10.1016/j.sleep.2018.08.021. View

Horne R, Wijayaratne P, Nixon G, Walter L . Sleep and sleep disordered breathing in children with down syndrome: Effects on behaviour, neurocognition and the cardiovascular system. Sleep Med Rev. 2018; 44:1-11. DOI: 10.1016/j.smrv.2018.11.002. View

Hyde M, ODriscoll D, Binette S, Galang C, Tan S, Verginis N . Validation of actigraphy for determining sleep and wake in children with sleep disordered breathing. J Sleep Res. 2007; 16(2):213-6. DOI: 10.1111/j.1365-2869.2007.00588.x. View

Brugha T, Bebbington P, Tennant C, Hurry J . The List of Threatening Experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychol Med. 1985; 15(1):189-94. DOI: 10.1017/s003329170002105x. View

10.

Yau S, Pickering R, Gringras P, Elphick H, Evans H, Farquhar M . Sleep in infants and toddlers with Down syndrome compared to typically developing peers: looking beyond snoring. Sleep Med. 2019; 63:88-97. DOI: 10.1016/j.sleep.2019.05.005. View

11.

Owens J, Spirito A, McGuinn M . The Children's Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep. 2001; 23(8):1043-51. View

12.

Gwyther A, Walters A, Hill C . Rhythmic movement disorder in childhood: An integrative review. Sleep Med Rev. 2016; 35:62-75. DOI: 10.1016/j.smrv.2016.08.003. View

13.

Nisbet L, Phillips N, Hoban T, OBrien L . Characterization of a sleep architectural phenotype in children with Down syndrome. Sleep Breath. 2014; 19(3):1065-71. DOI: 10.1007/s11325-014-1094-6. View

14.

Esbensen A, Hoffman E, Stansberry E, Shaffer R . Convergent validity of actigraphy with polysomnography and parent reports when measuring sleep in children with Down syndrome. J Intellect Disabil Res. 2018; 62(4):281-291. PMC: 5847446. DOI: 10.1111/jir.12464. View

15.

Maris M, Verhulst S, Wojciechowski M, Van de Heyning P, Boudewyns A . Prevalence of Obstructive Sleep Apnea in Children with Down Syndrome. Sleep. 2015; 39(3):699-704. PMC: 4763351. DOI: 10.5665/sleep.5554. View

16.

Magyar C, Pandolfi V, Dill C . An initial evaluation of the Social Communication Questionnaire for the assessment of autism spectrum disorders in children with Down syndrome. J Dev Behav Pediatr. 2012; 33(2):134-45. DOI: 10.1097/DBP.0b013e318240d3d9. View

17.

Goodman R . Psychometric properties of the strengths and difficulties questionnaire. J Am Acad Child Adolesc Psychiatry. 2001; 40(11):1337-45. DOI: 10.1097/00004583-200111000-00015. View

18.

Edgin J, Tooley U, Demara B, Nyhuis C, Anand P, Spano G . Sleep Disturbance and Expressive Language Development in Preschool-Age Children With Down Syndrome. Child Dev. 2015; 86(6):1984-98. PMC: 4626407. DOI: 10.1111/cdev.12443. View

19.

Groswasser J, Sottiaux M, Rebuffat E, Simon T, Vandeweyer M, Kelmanson I . Reduction in obstructive breathing events during body rocking: a controlled polygraphic study in preterm and full-term infants. Pediatrics. 1995; 96(1 Pt 1):64-8. View

20.

Ohayon M, Wickwire E, Hirshkowitz M, Albert S, Avidan A, Daly F . National Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017; 3(1):6-19. DOI: 10.1016/j.sleh.2016.11.006. View