Evaluation of the Effects of Fucoidans from Species and Against Oxidative Stress and Iron-Dependent Cell Death

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2021 Oct 22

PMID 34677456

Citations 12

Authors

Philipp Dorschmann

Sarah Apitz

Inga Hellige

Sandesh Neupane

Susanne Alban

Georg Kopplin

Signe Ptak

Xavier Frette

Johann Roider

Marietta Zille

Alexa Klettner

Affiliations

Soon will be listed here.

Abstract

Fucoidans are algal polysaccharides that exhibit protective properties against oxidative stress. The aim of this study was to investigate different fucoidans from brown seaweeds for their ability to protect against iron-dependent oxidative stress (ferroptosis), a main hallmark of retinal and brain diseases, including hemorrhage. We investigated five new high-molecular weight fucoidan extracts from , , and subsp. , a previously published extract, and commercially available extracts from and . We induced oxidative stress by glutathione depletion (erastin) and HO in four retinal and neuronal cell lines as well as primary cortical neurons. Only extracts from , subsp. , and were partially protective against erastin-induced cell death in ARPE-19 and OMM-1 cells, while none of the extracts showed beneficial effects in neuronal cells. Protective fucoidans also attenuated the decrease in protein levels of the antioxidant enzyme GPX4, a key regulator of ferroptosis. This comprehensive analysis demonstrates that the antioxidant abilities of fucoidans may be cell type-specific, besides depending on the algal species and extraction method. Future studies are needed to further characterize the health-benefiting effects of fucoidans and to determine the exact mechanism underlying their antioxidative abilities.

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