Bioengineering of Extracellular Vesicles: Exosome-Based Next-Generation Therapeutic Strategy in Cancer

Overview

Journal Bioengineering (Basel)

Date 2021 Oct 22

PMID 34677212

Citations 4

Authors

Priyanka Saha

Suchisnigdha Datta

Sukanya Ghosh

Anurima Samanta

Paramita Ghosh

Dona Sinha

Affiliations

Soon will be listed here.

Abstract

Extracellular nano vesicles and exosomes hold compelling evidence in intercellular communication. Exosomal intracellular signal transduction is mediated by the transfer of cargo proteins, lipids, micro (mi)RNAs, long noncoding (lnc)RNAs, small interfering (si)RNAs, DNA, and other functional molecules that play a pivotal role in regulating tumor growth and metastasis. However, emerging research trends indicate that exosomes may be used as a promising tool in anticancer treatment. This review features a majority of the bioengineering applications of fabricated exosomal cargoes. It also encompasses how the manipulation and delivery of specific cargoes-noncoding RNAs (ncRNAs), recombinant proteins, immune-modulators, chemotherapeutic drugs, and other small molecules-may serve as a precise therapeutic approach in cancer management.

Citing Articles

Stem Cell-Based Acellular Therapy: Insight into Biogenesis, Bioengineering and Therapeutic Applications of Exosomes.

Choudhery M, Arif T, Mahmood R, Harris D Biomolecules. 2024; 14(7).

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Exosomal long non-coding RNAs in cancer: Interplay, modulation, and therapeutic avenues.

Marima R, Basera A, Miya T, Damane B, Kandhavelu J, Mirza S Noncoding RNA Res. 2024; 9(3):887-900.

PMID: 38616862 PMC: 11015109. DOI: 10.1016/j.ncrna.2024.03.014.

Mesenchymal Stem Cell-Derived Exosomal microRNAs in Cardiac Regeneration.

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