Metabolism of Triglyceride-Rich Lipoproteins

Overview

Journal Handb Exp Pharmacol

Specialty Pharmacology

Date 2021 Oct 22

PMID 34676434

Citations 7

Authors

Jan Boren

Marja-Riitta Taskinen

Affiliations

Soon will be listed here.

Abstract

Triglycerides are critical lipids as they provide an energy source that is both compact and efficient. Due to its hydrophobic nature triglyceride molecules can pack together densely and so be stored in adipose tissue. To be transported in the aqueous medium of plasma, triglycerides have to be incorporated into lipoprotein particles along with other components such as cholesterol, phospholipid and associated structural and regulatory apolipoproteins. Here we discuss the physiology of normal triglyceride metabolism, and how impaired metabolism induces hypertriglyceridemia and its pathogenic consequences including atherosclerosis. We also discuss established and novel therapies to reduce triglyceride-rich lipoproteins.

Citing Articles

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