A Role for Mucolytics and Expectorants in Aiding Inhaled Therapies in Asthma? [Response To Letter]

Overview

Journal J Inflamm Res

Publisher Dove Medical Press

Date 2021 Oct 22

PMID 34675596

Authors

Ramesh J Kurukulaaratchy

Hitasha Rupani

Wei Chern Gavin Fong

Aref Kyyaly

Affiliations

Soon will be listed here.

Citing Articles

Dog allergen-induced asthma in mice: a relevant model of T2 severe asthma with airway remodelling.

Margelidon-Cozzolino V, Balsamelli J, Carrard J, Ait Yahia S, Gevaert M, Demoulin-Alexikova S Inflamm Res. 2025; 74(1):52.

PMID: 40082266 PMC: 11906515. DOI: 10.1007/s00011-025-02004-9.

References

Wenzel S, Vitari C, Shende M, Strollo D, Larkin A, Yousem S . Asthmatic granulomatosis: a novel disease with asthmatic and granulomatous features. Am J Respir Crit Care Med. 2012; 186(6):501-7. DOI: 10.1164/rccm.201203-0476OC. View

Morinaga Y, Yanagihara K, Miyashita N, Seki M, Izumikawa K, Kakeya H . Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells. Pulm Pharmacol Ther. 2009; 22(6):580-6. DOI: 10.1016/j.pupt.2009.08.004. View

Bonser L, Erle D . Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J Clin Med. 2017; 6(12). PMC: 5742801. DOI: 10.3390/jcm6120112. View

Rupani H, Fong W, Kyyaly A, Kurukulaaratchy R . Recent Insights into the Management of Inflammation in Asthma. J Inflamm Res. 2021; 14:4371-4397. PMC: 8421249. DOI: 10.2147/JIR.S295038. View

Millman M, Millman F, Goldstein I, Mercandetti A . Use of acetylcysteine in bronchial asthma--another look. Ann Allergy. 1985; 54(4):294-6. View

Juergens L, Worth H, Juergens U . New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach. Adv Ther. 2020; 37(5):1737-1753. PMC: 7467491. DOI: 10.1007/s12325-020-01279-0. View

Kostikas K, Clemens A, Patalano F . The asthma-COPD overlap syndrome: do we really need another syndrome in the already complex matrix of airway disease?. Int J Chron Obstruct Pulmon Dis. 2016; 11:1297-306. PMC: 4914074. DOI: 10.2147/COPD.S107307. View

Martinez-Rivera C, Crespo A, Pinedo-Sierra C, Garcia-Rivero J, Pallares-Sanmartin A, Marina-Malanda N . Mucus hypersecretion in asthma is associated with rhinosinusitis, polyps and exacerbations. Respir Med. 2018; 135:22-28. DOI: 10.1016/j.rmed.2017.12.013. View

Urakov A, Urakova N . Recent Insights into the Management of Inflammation in Asthma [Letter]. J Inflamm Res. 2021; 14:4603-4604. PMC: 8449642. DOI: 10.2147/JIR.S337690. View

10.

Garcia-Clemente M, Enriquez-Rodriguez A, Iscar-Urrutia M, Escobar-Mallada B, Arias-Guillen M, Lopez-Gonzalez F . Severe asthma and bronchiectasis. J Asthma. 2019; 57(5):505-509. DOI: 10.1080/02770903.2019.1579832. View

11.

Gibson P, Yang I, Upham J, Reynolds P, Hodge S, James A . Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial. Lancet. 2017; 390(10095):659-668. DOI: 10.1016/S0140-6736(17)31281-3. View

12.

Morgan L, Jaramillo A, Shenoy S, Raclawska D, Emezienna N, Richardson V . Disulfide disruption reverses mucus dysfunction in allergic airway disease. Nat Commun. 2021; 12(1):249. PMC: 7801631. DOI: 10.1038/s41467-020-20499-0. View

13.

Appelboam A, Dargan P, Knighton J . Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emerg Med J. 2002; 19(6):594-5. PMC: 1756296. DOI: 10.1136/emj.19.6.594. View

14.

Agusti A, Bel E, Thomas M, Vogelmeier C, Brusselle G, Holgate S . Treatable traits: toward precision medicine of chronic airway diseases. Eur Respir J. 2016; 47(2):410-9. DOI: 10.1183/13993003.01359-2015. View

15.

Mistry H, Ajsivinac Soberanis H, Kyyaly M, Azim A, Barber C, Knight D . The Clinical Implications of Aspergillus Fumigatus Sensitization in Difficult-To-Treat Asthma Patients. J Allergy Clin Immunol Pract. 2021; 9(12):4254-4267.e10. DOI: 10.1016/j.jaip.2021.08.038. View

16.

Bos I, Gosens R, Zuidhof A, Schaafsma D, Halayko A, Meurs H . Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison. Eur Respir J. 2007; 30(4):653-61. DOI: 10.1183/09031936.00004907. View

17.

Poole P, Sathananthan K, Fortescue R . Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2019; 5:CD001287. PMC: 6527426. DOI: 10.1002/14651858.CD001287.pub6. View