Molecular Docking Analysis of Human JAK2 with Compounds from Tomatoes
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Abstract
Janus kinase 2 (JAK2) is a tyrosine kinase receptor that belongs to the JAK family kinases is linked to oral cancer. We describe the molecular binding analysis of JAK2 with 23 compounds from tomotoes. Docking data shows five compounds (rutin, qucertin, narigenin, chlrogenia acid & kaempferol) with optimal binding features with JAK2 for further consideration.
References
1.
Lim S, Rahman M, Tejo B
. Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus. BMC Bioinformatics. 2012; 12 Suppl 13:S24.
PMC: 3278841.
DOI: 10.1186/1471-2105-12-S13-S24.
View
2.
Zhang Y, He J, He B, Huang R, Li M
. Effect of tobacco on periodontal disease and oral cancer. Tob Induc Dis. 2019; 17:40.
PMC: 6662776.
DOI: 10.18332/tid/106187.
View
3.
Morris G, Huey R, Lindstrom W, Sanner M, Belew R, Goodsell D
. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem. 2009; 30(16):2785-91.
PMC: 2760638.
DOI: 10.1002/jcc.21256.
View
4.
Sen M, Pollock N, Black J, DeGrave K, Wheeler S, Freilino M
. JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth. Neoplasia. 2015; 17(3):256-64.
PMC: 4372647.
DOI: 10.1016/j.neo.2015.01.003.
View
5.
Elango J, Gangadharan P, Sumithra S, Kuriakose M
. Trends of head and neck cancers in urban and rural India. Asian Pac J Cancer Prev. 2006; 7(1):108-12.
View