» Articles » PMID: 34675400

Translating the Advanced Glycation End Products (AGEs) Knowledge into Real-world Nutrition Strategies

Overview
Journal Eur J Clin Nutr
Date 2021 Oct 22
PMID 34675400
Citations 5
Authors
Affiliations
Soon will be listed here.
Abstract

Advanced glycation end products (AGEs) are glycated proteins or lipids derived from complex metabolic pathways involved in the pathophysiology of various diseases, especially diabetes and diabetes-related complications. These compounds are omnipresent in human life, with both endogenous and exogenous sources. Despite the well-elucidated disease mechanisms, little is known about the AGEs/nutrition nexus in the circles of clinical practice recommendations. This review seeks to translate the accumulated knowledge about the biochemistry and pathophysiology of AGEs into a nutritional intervention based on real-world prescriptions.

Citing Articles

Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.

Csiha S, Hernyak M, Molnar A, Lorincz H, Katko M, Paragh G Biomedicines. 2025; 13(2).

PMID: 40002851 PMC: 11852413. DOI: 10.3390/biomedicines13020438.


Effects of low-carbohydrate diets, with and without caloric restriction, on inflammatory markers in adults: a systematic review and meta-analysis of randomized clinical trials.

Kazeminasab F, Miraghajani M, Khalafi M, Sakhaei M, Rosenkranz S, Santos H Eur J Clin Nutr. 2024; 78(7):569-584.

PMID: 38499791 DOI: 10.1038/s41430-024-01431-x.


Association between dietary glycemic index and non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus.

Salavatizadeh M, Soltanieh S, Kachouei A, Abdollahi Fallahi Z, Kord-Varkaneh H, Poustchi H Front Endocrinol (Lausanne). 2023; 14:1228072.

PMID: 37674617 PMC: 10478091. DOI: 10.3389/fendo.2023.1228072.


Editorial: Functional foods, supplements, and dietary approaches in sports and clinical nutrition.

Santos H, Forbes S, Gaman M Front Nutr. 2023; 10:1203477.

PMID: 37215222 PMC: 10196615. DOI: 10.3389/fnut.2023.1203477.


Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial.

Kord Varkaneh H, Salehi Sahlabadi A, Gaman M, Rajabnia M, Macit-Celebi M, Santos H Front Nutr. 2022; 9:948655.

PMID: 35958257 PMC: 9360602. DOI: 10.3389/fnut.2022.948655.


References
1.
Castro J, El-Atat F, McFarlane S, Aneja A, Sowers J . Cardiometabolic syndrome: pathophysiology and treatment. Curr Hypertens Rep. 2003; 5(5):393-401. DOI: 10.1007/s11906-003-0085-y. View

2.
Jha J, Banal C, Chow B, Cooper M, Jandeleit-Dahm K . Diabetes and Kidney Disease: Role of Oxidative Stress. Antioxid Redox Signal. 2016; 25(12):657-684. PMC: 5069735. DOI: 10.1089/ars.2016.6664. View

3.
Goldin A, Beckman J, Schmidt A, Creager M . Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006; 114(6):597-605. DOI: 10.1161/CIRCULATIONAHA.106.621854. View

4.
Vlassara H, Striker G . AGE restriction in diabetes mellitus: a paradigm shift. Nat Rev Endocrinol. 2011; 7(9):526-39. PMC: 3708644. DOI: 10.1038/nrendo.2011.74. View

5.
Ostry A, Young M, Hughes M . The quality of nutritional information available on popular websites: a content analysis. Health Educ Res. 2007; 23(4):648-55. DOI: 10.1093/her/cym050. View