» Articles » PMID: 34671160

Ethics of DNA Research on Human Remains: Five Globally Applicable Guidelines

Abstract

We are a group of archaeologists, anthropologists, curators and geneticists representing diverse global communities and 31 countries. All of us met in a virtual workshop dedicated to ethics in ancient DNA research held in November 2020. There was widespread agreement that globally applicable ethical guidelines are needed, but that recent recommendations grounded in discussion about research on human remains from North America are not always generalizable worldwide. Here we propose the following globally applicable guidelines, taking into consideration diverse contexts. These hold that: (1) researchers must ensure that all regulations were followed in the places where they work and from which the human remains derived; (2) researchers must prepare a detailed plan prior to beginning any study; (3) researchers must minimize damage to human remains; (4) researchers must ensure that data are made available following publication to allow critical re-examination of scientific findings; and (5) researchers must engage with other stakeholders from the beginning of a study and ensure respect and sensitivity to stakeholder perspectives. We commit to adhering to these guidelines and expect they will promote a high ethical standard in DNA research on human remains going forward.

Citing Articles

Admixture as a source for HLA variation in Neolithic European farming communities.

da Silva N, Ozer O, Haller-Caskie M, Chen Y, Kolbe D, Schade-Lindig S Genome Biol. 2025; 26(1):43.

PMID: 40022192 PMC: 11869582. DOI: 10.1186/s13059-025-03509-6.


Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans.

Krause-Kyora B, da Silva N, Kaplan E, Kolbe D, Wohlers I, Busch H EBioMedicine. 2025; 113:105591.

PMID: 39923740 PMC: 11849592. DOI: 10.1016/j.ebiom.2025.105591.


Stable isotope evidence for pre-colonial maize agriculture and animal management in the Bolivian Amazon.

Hermenegildo T, Hermengildo T, Prumers H, Jaimes Betancourt C, Roberts P, OConnell T Nat Hum Behav. 2024; .

PMID: 39715871 DOI: 10.1038/s41562-024-02070-9.


Social and genetic diversity in first farmers of central Europe.

Gelabert P, Bickle P, Hofmann D, Teschler-Nicola M, Anders A, Huang X Nat Hum Behav. 2024; 9(1):53-64.

PMID: 39613963 PMC: 11774665. DOI: 10.1038/s41562-024-02034-z.


Big Epidemiology: The Birth, Life, Death, and Resurgence of Diseases on a Global Timescale.

Bragazzi N, Lehr T Epidemiologia (Basel). 2024; 5(4):669-691.

PMID: 39584937 PMC: 11586986. DOI: 10.3390/epidemiologia5040047.


References
1.
Austin R, Sholts S, Williams L, Kistler L, Hofman C . Opinion: To curate the molecular past, museums need a carefully considered set of best practices. Proc Natl Acad Sci U S A. 2019; 116(5):1471-1474. PMC: 6358678. DOI: 10.1073/pnas.1822038116. View

2.
Bardill J, Bader A, Garrison N, Bolnick D, Raff J, Walker A . Advancing the ethics of paleogenomics. Science. 2018; 360(6387):384-385. PMC: 6150602. DOI: 10.1126/science.aaq1131. View

3.
Claw K, Anderson M, Begay R, Tsosie K, Fox K, Garrison N . A framework for enhancing ethical genomic research with Indigenous communities. Nat Commun. 2018; 9(1):2957. PMC: 6063854. DOI: 10.1038/s41467-018-05188-3. View

4.
Claw K, Lippert D, Bardill J, Cordova A, Fox K, Yracheta J . Chaco Canyon Dig Unearths Ethical Concerns. Hum Biol. 2018; 89(3):177-180. PMC: 5951383. DOI: 10.13110/humanbiology.89.3.01. View

5.
Eisenmann S, Banffy E, van Dommelen P, Hofmann K, Maran J, Lazaridis I . Reconciling material cultures in archaeology with genetic data: The nomenclature of clusters emerging from archaeogenomic analysis. Sci Rep. 2018; 8(1):13003. PMC: 6115390. DOI: 10.1038/s41598-018-31123-z. View