Metabolomic Analysis Reveals the Adaptation in the P. Przewalskii to Se-Deprived Environment

Overview

Journal Biol Trace Elem Res

Date 2021 Oct 20

PMID 34669150

Authors

Qionglian Zhang

Kui Zhao

Xiaoyun Shen

Affiliations

Soon will be listed here.

Abstract

The Procapra przewalskii inhabits in a selenium (Se)-deprived environment in long-term, but they have no pathological manifestations due to the Se deprivation. This study aimed to reveal the underlying adaptation induced by Se deprivation. In the analysis, a total of 93 significantly changed metabolites were identified in positive and negative ion modes, including 46 upregulated and 47 downregulated compounds in the Se-deprived group. The differential metabolites were annotated as the major molecules in bile acid biosynthesis, biosynthesis of unsaturated fatty acids, and pyrimidine metabolism, respectively. This study systematically analyzed the serum metabolomics characteristics of P. przewalskii under Se-deprived conditions for the first time, providing a basis for further understanding of the metabolic mechanism of P. przewalskii in the Se-deprived environment.

References

Hu J, Jiang Z . Climate change hastens the conservation urgency of an endangered ungulate. PLoS One. 2011; 6(8):e22873. PMC: 3149626. DOI: 10.1371/journal.pone.0022873. View

Wang Y, Du S, Yang Y, Zhang X, Duszynski D, Bian J . Intestinal Parasites in the Critically Endangered Przewalski's Gazelle ( Procapra przewalskii ) in China, with the Description of a New Species of Eimeria (Apicomplexa: Eimeriidae). J Wildl Dis. 2016; 52(4):945-948. DOI: 10.7589/2016-03-062. View

Li C, Jiang Z, Fang H, Li C . A spatially explicit model of functional connectivity for the endangered Przewalski's gazelle (Procapra przewalskii) in a patchy landscape. PLoS One. 2013; 8(11):e80065. PMC: 3826712. DOI: 10.1371/journal.pone.0080065. View

Yu H, Song S, Liu J, Li S, Zhang L, Wang D . Effects of the Qinghai-Tibet Railway on the Landscape Genetics of the Endangered Przewalski's Gazelle (Procapra przewalskii). Sci Rep. 2017; 7(1):17983. PMC: 5740140. DOI: 10.1038/s41598-017-18163-7. View

Li C, Jiang Z, Li L, Li Z, Fang H, Li C . Effects of reproductive status, social rank, sex and group size on vigilance patterns in Przewalski's gazelle. PLoS One. 2012; 7(2):e32607. PMC: 3289666. DOI: 10.1371/journal.pone.0032607. View

Boussada M, Ben Ali R, Chahbi A, Abdelkarim M, Fradj M, Dziri C . A new Thiocyanoacetamide protects rat sperm cells from Doxorubicin-triggered cytotoxicity whereas Selenium shows low efficacy: In vitro approach. Toxicol In Vitro. 2019; 61:104587. DOI: 10.1016/j.tiv.2019.06.021. View

Zhao K, Huo B, Shen X . Studies on Antioxidant Capacity in Selenium-Deprived the Choko Yak in the Shouqu Prairie. Biol Trace Elem Res. 2020; 199(9):3297-3302. DOI: 10.1007/s12011-020-02461-9. View

Huo B, He J, Shen X . Effects of Selenium-Deprived Habitat on the Immune Index and Antioxidant Capacity of Przewalski's Gazelle. Biol Trace Elem Res. 2020; 198(1):149-156. DOI: 10.1007/s12011-020-02070-6. View

Song C, Jiang Q, Shen X . Responses of Przewalski's Gazelle (Procapra przewalskii) to Zinc Nutrition in Physical Habitat. Biol Trace Elem Res. 2020; 199(1):142-147. DOI: 10.1007/s12011-020-02137-4. View

10.

Song C, Shen X . Effects of Environmental Zinc Deficiency on Antioxidant System Function in Wumeng Semi-fine Wool Sheep. Biol Trace Elem Res. 2019; 195(1):110-116. DOI: 10.1007/s12011-019-01840-1. View

11.

Shen X, Min X, Zhang S, Song C, Xiong K . Effect of Heavy Metal Contamination in the Environment on Antioxidant Function in Wumeng Semi-fine Wool Sheep in Southwest China. Biol Trace Elem Res. 2020; 198(2):505-514. DOI: 10.1007/s12011-020-02081-3. View

12.

Xu S, Yao H, Zhang J, Zhang Z, Wang J, Zhang J . The oxidative damage and disbalance of calcium homeostasis in brain of chicken induced by selenium deficiency. Biol Trace Elem Res. 2012; 151(2):225-33. DOI: 10.1007/s12011-012-9552-0. View

13.

Shen X, Song C . Responses of Chinese Merino Sheep (Junken Type) on Copper-Deprived Natural Pasture. Biol Trace Elem Res. 2020; 199(3):989-995. DOI: 10.1007/s12011-020-02214-8. View

14.

Liu J, Jiang Y, Huang C, Fang H, Fang H, Pang W . Proteomic analysis reveals changes in the hippocampus protein pattern of rats exposed to dietary zinc deficiency. Electrophoresis. 2010; 31(8):1302-10. DOI: 10.1002/elps.200900733. View

15.

Chan Y, Siu C, Yiu K, Chan H, Li S, Tam S . Adverse systemic arterial function in patients with selenium deficiency. J Nutr Health Aging. 2012; 16(1):85-8. DOI: 10.1007/s12603-011-0086-5. View

16.

Deger Y, Mert H, Mert N, Yur F, Kozat S, Yoruk I . Serum selenium, vitamin E, and sialic acids concentrations in lambs with white muscle disease. Biol Trace Elem Res. 2008; 121(1):39-43. DOI: 10.1007/s12011-007-0063-3. View

17.

Li Y, He J, Shen X . Effects of Nano-selenium Poisoning on Immune Function in the Wumeng Semi-fine Wool Sheep. Biol Trace Elem Res. 2020; 199(8):2919-2924. DOI: 10.1007/s12011-020-02408-0. View

18.

Zhao K, Chi Y, Shen X . Studies on Edema Pathema in Hequ Horse in the Qinghai-Tibet Plateau. Biol Trace Elem Res. 2020; 198(1):142-148. DOI: 10.1007/s12011-020-02043-9. View

19.

Peng S, Yan L, Zhang J, Wang Z, Tian M, Shen H . An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid. J Pharm Biomed Anal. 2013; 86:56-64. DOI: 10.1016/j.jpba.2013.07.014. View

20.

Nicholson J, Lindon J, Holmes E . 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999; 29(11):1181-9. DOI: 10.1080/004982599238047. View