The Effect of Ultraviolet Irradiation Compared to Oral Vitamin D Supplementation on Blood Pressure of Nursing Home Residents with Dementia

Overview

Journal BMC Geriatr

Publisher Biomed Central

Specialty Geriatrics

Date 2021 Oct 20

PMID 34666693

Citations 1

Authors

Bistra I Veleva

Monique A A Caljouw

Astrid Muurman

Jenny T van der Steen

Victor G M Chel

Mattijs E Numans

Rosalinde K E Poortvliet

Affiliations

Soon will be listed here.

Abstract

Background: Observational studies have reported an inverse association between ultraviolet (UV) radiation and hypertension. The aim of this study was to assess differences in blood pressure changes between persons with dementia receiving UV light versus vitamin D (VD) supplementation.

Methods: Post-hoc analysis of randomized controlled trial data concerning nursing home residents with dementia (N = 61; 41 women, mean age 84.8 years). The participants received half-body UV irradiation, twice weekly over 6 months, at one standard erythema dose (UV group, n = 22) or 5600 international units of cholecalciferol once a week (VD group, n = 39). Short-term effects were evaluated after 1 month and long-term effects after 3 and 6 months. Differences in blood pressure changes were assessed using linear mixed models.

Results: With the VD group as a reference, the estimated difference in mean change of systolic blood pressure was - 26.0 mmHg [95% confidence interval (CI) -39.9, - 12.1, p = .000] at 1 month, 4.5 mmHg (95% CI -6.8, 15.9, p = 0.432) at 3 months, and 0.1 (95% CI -14.1, 14.3, p = 0.83) at 6 months. The estimated difference in diastolic blood pressure was - 10.0 mmHg (95% CI -19.2, - 0.7, p = 0.035) at 1 month, 3.6 mmHg (95% CI -4.1, 11.2, p = 0.358) at 3 months, and 2.7 (95% CI -6.8, 12.1, p = 0.580) at 6 months.

Conclusions: UV light had only a short-term effect but not a long-term effect on blood pressure reduction compared to VD use in this sample of normotensive to mild hypertensive nursing home residents with dementia. Future studies will be needed to determine the effect of UV light in different samples of the population and especially in a population with hypertension.

Citing Articles

Longitudinal real world correlation study of blood pressure and novel features of cerebral magnetic resonance angiography by artificial intelligence analysis on elderly cognitive impairment.

Sun S, Liu D, Zhou Y, Yang G, Cui L, Xu X Front Aging Neurosci. 2023; 15:1121152.

PMID: 36819723 PMC: 9935573. DOI: 10.3389/fnagi.2023.1121152.

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