Itaconate As an Inflammatory Mediator and Therapeutic Target in Cardiovascular Medicine

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2021 Oct 19

PMID 34665229

Citations 6

Authors

Marina Diotallevi

Faseeha Ayaz

Thomas Nicol

Mark J Crabtree

Affiliations

Soon will be listed here.

Abstract

Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has been placed centrally in the governance of the immune response. Termed immunometabolism, immune cells adapt cellular metabolic pathways to meet demands of activation and thus function. This rewiring influences not only the bioenergetics of the cell but altered metabolites act as signalling molecules to regulate cellular response. In this review, we focus on the TCA cycle derivative, itaconate, as one such metabolite with promising immunomodulatory and therapeutic potential in inflammatory cardiovascular disease.

Citing Articles

The Development and Characterization of Two Monoclonal Antibodies Against the Conjugates and Derivatives of the Immunometabolite Itaconate.

Switala L, Di L, Colantonio S, Lakshman B, Caceres T, Reading J ACS Omega. 2025; 10(1):1110-1121.

PMID: 39829496 PMC: 11740141. DOI: 10.1021/acsomega.4c08552.

Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution.

Hong N, Chaplin A, Di L, Ravodina A, Bevan G, Gao H Cell Rep. 2024; 43(11):114911.

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Metabolite signaling in the heart.

Flam E, Arany Z Nat Cardiovasc Res. 2024; 2(6):504-516.

PMID: 39195876 DOI: 10.1038/s44161-023-00270-6.

Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases.

Hang L, Zhang Y, Zhang Z, Jiang H, Xia L Cardiovasc Drugs Ther. 2024; .

PMID: 38236378 DOI: 10.1007/s10557-024-07545-5.

Itaconic acid facilitates inflammation abatement and alleviates liver ischemia-reperfusion injury by inhibiting NF-κB/NLRP3/caspase-1 inflammasome axis.

Ma E, Xing H, Pei J, Zhang Q, Li R, Shen C Ann Transl Med. 2022; 10(16):861.

PMID: 36111043 PMC: 9469154. DOI: 10.21037/atm-22-3388.

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