Advances in Pathogenesis of Sjögren's Syndrome

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2021 Oct 18

PMID 34660815

Citations 15

Authors

Yao Tian

Hongyi Yang

Na Liu

Yan Li

Jie Chen

Affiliations

Soon will be listed here.

Abstract

Sjögren's syndrome (SS) is a chronic autoimmune disease of unknown etiology that mainly involves exocrine glands. Patients present with dry mouth and eyes, fever, arthralgia, and other systemic symptoms. In severe cases, the quality of life of patients is affected. At present, there is no cure for SS, and the treatment options are extremely limited. In recent years, studies of patients and animal models have identified abnormalities of immune cell function and cytokines to be involved in SS. A systematic review of the literature may clarify the etiology and pathogenesis of SS, as well as provide a theoretical basis for the development of new drugs for the treatment of SS.

Citing Articles

Metabolic changes during evolution of Sjögren's in both an animal model and human patients.

Jacob A, He J, Peck A, Jamil A, Bunya V, Alexander J Heliyon. 2025; 11(1):e41082.

PMID: 39801970 PMC: 11720936. DOI: 10.1016/j.heliyon.2024.e41082.

Salivary Flow Rate in Patients with Sjögren's Syndrome: Correlations with Salivary Gland Ultrasound Findings and Biomarkers of Disease Activity.

Caraba A, Roman D, Crisan V, Iurciuc S, Iurciuc M Int J Mol Sci. 2025; 26(1.

PMID: 39795957 PMC: 11720050. DOI: 10.3390/ijms26010101.

Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren's syndrome via suppression of the CX3CL1/CX3CR1 axis.

Yang Z, Liu M, Chang Z, Du C, Yang Y, Zhang C Front Immunol. 2024; 15:1465938.

PMID: 39497829 PMC: 11532040. DOI: 10.3389/fimmu.2024.1465938.

Biological functions and affected signaling pathways by Long Non-Coding RNAs in the immune system.

Ghahramani Almanghadim H, Karimi B, Valizadeh S, Ghaedi K Noncoding RNA Res. 2024; 10:70-90.

PMID: 39315339 PMC: 11417496. DOI: 10.1016/j.ncrna.2024.09.001.

Chemokines and lymphocyte homing in Sjögren's syndrome.

Liao J, Yu X, Huang Z, He Q, Yang J, Zhang Y Front Immunol. 2024; 15:1345381.

PMID: 38736890 PMC: 11082322. DOI: 10.3389/fimmu.2024.1345381.

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