Application of Deep Convolution Network to Automated Image Segmentation of Chest CT for Patients With Tumor

Objectives: To automate image delineation of tissues and organs in oncological radiotherapy by combining the deep learning methods of fully convolutional network (FCN) and atrous convolution (AC).

Methods: A total of 120 sets of chest CT images of patients were selected, on which radiologists had outlined the structures of normal organs. Of these 120 sets of images, 70 sets (8,512 axial slice images) were used as the training set, 30 sets (5,525 axial slice images) as the validation set, and 20 sets (3,602 axial slice images) as the test set. We selected 5 published FCN models and 1 published Unet model, and then combined FCN with AC algorithms to generate 3 improved deep convolutional networks, namely, dilation fully convolutional networks (D-FCN). The images in the training set were used to fine-tune and train the above 8 networks, respectively. The images in the validation set were used to validate the 8 networks in terms of the automated identification and delineation of organs, in order to obtain the optimal segmentation model of each network. Finally, the images of the test set were used to test the optimal segmentation models, and thus we evaluated the capability of each model of image segmentation by comparing their Dice coefficients between automated and physician delineation.

Results: After being fully tuned and trained with the images in the training set, all the networks in this study performed well in automated image segmentation. Among them, the improved D-FCN 4s network model yielded the best performance in automated segmentation in the testing experiment, with an global Dice of 87.11%, and a Dice of 87.11%, 97.22%, 97.16%, 89.92%, and 70.51% for left lung, right lung, pericardium, trachea, and esophagus, respectively.

Conclusion: We proposed an improved D-FCN. Our results showed that this network model might effectively improve the accuracy of automated segmentation of the images in thoracic radiotherapy, and simultaneously perform automated segmentation of multiple targets.