Long Non-Coding RNA NRON Promotes Tumor Proliferation by Regulating ALKBH5 and Nanog in Gastric Cancer

Overview

Journal J Cancer

Specialty Oncology

Date 2021 Oct 18

PMID 34659574

Citations 17

Authors

Shuchang Wang

Yangyang Wang

Zizhen Zhang

Chunchao Zhu

Chaojie Wang

Fengrong Yu

Enhao Zhao

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In this study, we explored the expression and biological role of lncRNA NRON in gastric cancer (GC). We observed that lncNRON was upregulated in GC tissues and cell lines, and high lncNRON expression was associated with malignant features and poor prognosis in GC patients. LncNRON was found to promote the proliferation and tumorigenicity of GC cells. Mechanistically, lncNRON exerted its oncogenic functions by binding to the N6-methyladenosine eraser ALKHB5 and mediating Nanog mRNA decay. In conclusion, our results suggest that lncNRON serves as an oncogenic lncRNA in GC and thus may be a promising prognostic factor and potential therapeutic target for GC patients.

Citing Articles

Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review).

Dai C, Qianjiang H, Fu R, Yang H, Shi A, Luo H Int J Oncol. 2025; 66(4).

PMID: 40017127 PMC: 11900940. DOI: 10.3892/ijo.2025.5735.

Role of the mA demethylase ALKBH5 in gastrointestinal tract cancer (Review).

Zhang L, Jing M, Song Q, Ouyang Y, Pang Y, Ye X Int J Mol Med. 2024; 55(2).

PMID: 39611478 PMC: 11637504. DOI: 10.3892/ijmm.2024.5463.

Complicated role of ALKBH5 in gastrointestinal cancer: an updated review.

Shu W, Huang Q, Chen R, Lan H, Yu L, Cui K Cancer Cell Int. 2024; 24(1):298.

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The regulatory mechanism of m6A modification in gastric cancer.

Wu S, Li C, Zhou H, Yang Y, Liang N, Fu Y Discov Oncol. 2024; 15(1):283.

PMID: 39009956 PMC: 11250764. DOI: 10.1007/s12672-024-00994-2.

Overview of the interplay between m6A methylation modification and non-coding RNA and their impact on tumor cells.

Dou Z, Ma X, Piao M, Wang J, Li J Transl Cancer Res. 2024; 13(6):3106-3125.

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