Immunomodulatory Effects of Tryptophan Metabolism in the Glioma Tumor Microenvironment

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Oct 18

PMID 34659216

Citations 11

Authors

Yang Xu

Huikai Zhang

Qian Sun

Rongxin Geng

Fanen Yuan

Baohui Liu

Qianxue Chen

Affiliations

Soon will be listed here.

Abstract

Gliomas are the most common primary malignant tumor in adults' central nervous system. While current research on glioma treatment is advancing rapidly, there is still no breakthrough in long-term treatment. Abnormalities in the immune regulatory mechanism in the tumor microenvironment are essential to tumor cell survival. The alteration of amino acid metabolism is considered a sign of tumor cells, significantly impacting tumor cells and immune regulation mechanisms in the tumor microenvironment. Despite the fact that the metabolism of tryptophan in tumors is currently discussed in the literature, we herein focused on reviewing the immune regulation of tryptophan metabolism in the tumor microenvironment of gliomas and analyzed possible immune targets. The objective is to identify potential targets for the treatment of glioma and improve the efficiency of immunotherapy.

Citing Articles

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References

Feng X, Szulzewsky F, Yerevanian A, Chen Z, Heinzmann D, Rasmussen R . Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. Oncotarget. 2015; 6(17):15077-94. PMC: 4558137. DOI: 10.18632/oncotarget.3730. View

Opitz C, Litzenburger U, Sahm F, Ott M, Tritschler I, Trump S . An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011; 478(7368):197-203. DOI: 10.1038/nature10491. View

Nirschl C, Suarez-Farinas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I . IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell. 2017; 170(1):127-141.e15. PMC: 5569303. DOI: 10.1016/j.cell.2017.06.016. View

Han S, Ma E, Wang X, Yu C, Dong T, Zhan W . Rescuing defective tumor-infiltrating T-cell proliferation in glioblastoma patients. Oncol Lett. 2016; 12(4):2924-2929. PMC: 5038909. DOI: 10.3892/ol.2016.4944. View

Mayers J, Torrence M, Danai L, Papagiannakopoulos T, Davidson S, Bauer M . Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science. 2016; 353(6304):1161-5. PMC: 5245791. DOI: 10.1126/science.aaf5171. View

Cervenka I, Agudelo L, Ruas J . Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health. Science. 2017; 357(6349). DOI: 10.1126/science.aaf9794. View

Franklin R, Liao W, Sarkar A, Kim M, Bivona M, Liu K . The cellular and molecular origin of tumor-associated macrophages. Science. 2014; 344(6186):921-5. PMC: 4204732. DOI: 10.1126/science.1252510. View

Ahlstedt J, Konradsson E, Ceberg C, Nittby Redebrandt H . Increased effect of two-fraction radiotherapy in conjunction with IDO1 inhibition in experimental glioblastoma. PLoS One. 2020; 15(5):e0233617. PMC: 7259656. DOI: 10.1371/journal.pone.0233617. View

Munn D, Mellor A . IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance. Trends Immunol. 2016; 37(3):193-207. PMC: 4916957. DOI: 10.1016/j.it.2016.01.002. View

10.

Chen X, Zhang L, Zhang I, Liang J, Wang H, Ouyang M . RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma. Cancer Res. 2014; 74(24):7285-7297. PMC: 4268204. DOI: 10.1158/0008-5472.CAN-14-1240. View

11.

Ahmed K, Chinnaiyan P . Applying metabolomics to understand the aggressive phenotype and identify novel therapeutic targets in glioblastoma. Metabolites. 2014; 4(3):740-50. PMC: 4192690. DOI: 10.3390/metabo4030740. View

12.

Schreiber R, Old L, Smyth M . Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science. 2011; 331(6024):1565-70. DOI: 10.1126/science.1203486. View

13.

Nguyen N, Kimura A, Nakahama T, Chinen I, Masuda K, Nohara K . Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism. Proc Natl Acad Sci U S A. 2010; 107(46):19961-6. PMC: 2993339. DOI: 10.1073/pnas.1014465107. View

14.

Mu C, Yang Y, Yu K, Yu M, Zhang C, Su Y . Alteration of metabolomic markers of amino-acid metabolism in piglets with in-feed antibiotics. Amino Acids. 2017; 49(4):771-781. DOI: 10.1007/s00726-017-2379-4. View

15.

Agus A, Planchais J, Sokol H . Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. Cell Host Microbe. 2018; 23(6):716-724. DOI: 10.1016/j.chom.2018.05.003. View

16.

Le Floch N, Otten W, Merlot E . Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids. 2010; 41(5):1195-205. DOI: 10.1007/s00726-010-0752-7. View

17.

Molinier-Frenkel V, Prevost-Blondel A, Castellano F . The IL4I1 Enzyme: A New Player in the Immunosuppressive Tumor Microenvironment. Cells. 2019; 8(7). PMC: 6678094. DOI: 10.3390/cells8070757. View

18.

Reardon D, Desjardins A, Rixe O, Cloughesy T, Alekar S, Williams J . A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma. Invest New Drugs. 2020; 38(6):1784-1795. DOI: 10.1007/s10637-020-00950-1. View

19.

Quintana F, Sherr D . Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev. 2013; 65(4):1148-61. PMC: 3799235. DOI: 10.1124/pr.113.007823. View

20.

Huang Y, Kim B, Chan C, Hahn S, Weissman I, Jiang W . Improving immune-vascular crosstalk for cancer immunotherapy. Nat Rev Immunol. 2018; 18(3):195-203. PMC: 5922422. DOI: 10.1038/nri.2017.145. View