Effects of and Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 Oct 18

PMID 34659133

Citations 15

Authors

Bianca Bianco

Flavia Altheman Loureiro

Camila Martins Trevisan

Carla Peluso

Denise Maria Christofolini

Erik Montagna

Antonio Simone Lagana

Caio Parente Barbosa

Affiliations

Soon will be listed here.

Abstract

Background: Single nucleotide variants (SNVs) :c.-211G>T, :c.919G>A, and :c.2039G>A were reported to be associated with the variability in FSH and LH levels, and fertilization (IVF) outcomes. In this study, we aimed to evaluate the effects of :c.-211G>T, :c.919G>A, and c.2039G>A variants, alone and combined, on the hormonal profile and reproduction outcomes of women with endometriosis.

Methods: A cross-sectional study was performed comprising 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables were compared according to the genotypes of each variant and genetic models, and the combined effects of the SNVs were evaluated using the multifactorial dimensionality reduction method.

Results: :c.-211G>T affected LH levels in women with overall endometriosis and minimal/mild disease. :c.919G>A affected FSH levels in women with overall endometriosis and the number of oocytes retrieved in those with moderate/severe endometriosis. Moreover, the :c.2039G>A affected FSH levels in women with overall endometriosis, LH levels and total amount of rFSH in those with minimal/mild disease, and number of follicles and number of oocytes retrieved in those with moderate/severe endometriosis. No effect on hormone profile or reproductive outcomes was observed when the genotypes were combined.

Conclusions: Variants of the and genes separately interfered with the hormonal profiles and IVF outcomes of women with endometriosis.

Citing Articles

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Implication of FSHB rs10835638 variant in endometriosis in Brazilian women.

Bianco B, Loureiro F, Trevisan C, Christofolini D, Lagana A, Barbosa C Einstein (Sao Paulo). 2023; 21:eAO0483.

PMID: 37909652 PMC: 10586852. DOI: 10.31744/einstein_journal/2023AO0483.

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