Association Between YKL-40 and Asthma: a Systematic Meta-analysis

Overview

Journal Sleep Breath

Publisher Springer

Date 2021 Oct 17

PMID 34657273

Citations 6

Authors

Yihan Jin

Jie Song

Fang Xu

Di Zhang

Jinfang He

Jiakun Zheng

Yanan Zhang

Jintong Li

Yikun Guo

Mengjiao Xu

Xiangfeng Yu

Yanbin Liu

Qinghua Liu

Jun Yan

Affiliations

Soon will be listed here.

Abstract

Purpose: Many studies have shown that chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is associated with asthma. The purpose of this meta-analysis was to evaluate the role of serum YKL-40 in the diagnosis and differential diagnosis of asthma, severity grading, and determination of disease state.

Methods: The PubMed, Ovid, and Cochrane databases were searched. A total of 17 articles involving 5696 subjects were included in this meta-analysis.

Results: The results showed that the level of YKL-40 was significantly higher in asthmatic patients than in the normal group regardless of age and residential location, and increased with severity and acute exacerbation (p < 0.05). YKL-40 levels were significantly different between chronic obstructive pulmonary disease (COPD) and asthma, and also between asthma-COPD overlap syndrome (ACO) and asthma (p < 0.05).

Conclusion: YKL-40 may act as a potential serological marker for the diagnosis of asthma, assessment of severity, indicator of the disease state, and differential diagnosis of COPD, ACO, and asthma.

Citing Articles

Inflammatory Effects and Regulatory Mechanisms of Chitinase-3-like-1 in Multiple Human Body Systems: A Comprehensive Review.

Liu D, Hu X, Ding X, Li M, Ding L Int J Mol Sci. 2025; 25(24.

PMID: 39769202 PMC: 11678640. DOI: 10.3390/ijms252413437.

The Relation of Insulin Resistance With Free Androgen Index and Endothelial Dysfunction Marker YKL-40 and Its Effect on Male Infertility: A Prospective Study.

Yilmaz M, Keyif B Cureus. 2024; 16(10):e72481.

PMID: 39600764 PMC: 11590756. DOI: 10.7759/cureus.72481.

Location-based prediction model for Crohn's disease regarding a novel serological marker, anti-chitinase 3-like 1 autoantibodies.

Sipeki N, Kovats P, Deutschmann C, Schierack P, Roggenbuck D, Papp M World J Gastroenterol. 2023; 29(42):5728-5750.

PMID: 38075846 PMC: 10701337. DOI: 10.3748/wjg.v29.i42.5728.

Bronchial Asthma, Airway Remodeling and Lung Fibrosis as Successive Steps of One Process.

Savin I, Zenkova M, Senkova A Int J Mol Sci. 2023; 24(22).

PMID: 38003234 PMC: 10671561. DOI: 10.3390/ijms242216042.

Phenotypes and Endotypes in Asthma.

McIntyre A, Viswanathan R Adv Exp Med Biol. 2023; 1426:119-142.

PMID: 37464119 DOI: 10.1007/978-3-031-32259-4_6.

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