Prevalence of Infection by Human T Cell Lymphotropic Viruses (HTLV-1/2) in Adult Population in Vitória-ES

Overview

Journal Braz J Infect Dis

Specialty Infectious Diseases

Date 2021 Oct 17

PMID 34656523

Citations 2

Authors

Maria P S Orletti

Tatiane Assone

Glenia Daros Sarnaglia

Marina Lobato Martins

Carolina Rosadas

Jorge Casseb

Graham Taylor

Joaquim B Ferreira-Filho

Fausto E L Pereira

Angelica Espinosa Miranda

Affiliations

Soon will be listed here.

Abstract

Introduction: Brazil has a high number of HTLV-1/2 infections which are unequally distributed in the country. Most prevalence studies have focused on specific populations, such as blood donors and pregnant women. Some areas, for example the state of Bahia, have robust information about HTLV-1/2 infection, however there is no information available about this infection in the general population of Vitória, Espírito Santo, Brazil.

Objective: To determine the prevalence of HTLV-1/2 infection in adults from the municipality of Vitoria, ES.

Methods: A cross sectional study was performed from September 2010 to December 2011, in individuals of both sexes, aged 18 or older living in Vitória-ES. Venous blood samples were collected and tested for anti-HTLV-1/2 antibodies by chemiluminescent immunoassay (CMIA). Individuals with CMIA reactive results were submitted to a new blood collection for retesting by CMIA, followed by PCR to confirm infection and discriminate the viral type.

Results: From 1502 tested samples, eight were reactive in CMIA and all were confirmed by PCR. Therefore, the prevalence of HTLV-1/2 was 0.53% (8/1502, 95% CI: 0.2-1.0%). The infection rate was 0.7% in men (5/711, 95% CI: 0.17-1.51%), and 0.38% in women (3/791, 95% CI: 0-0.81%).

Conclusions: The prevalence of HTLV-1/2 infection was 0.53% (8/1502; 95% CI: 0.2-0.9%). Confirmatory test using real-time PCR (qPCR) identified seven individuals positive for HTLV-1 and one for HTLV-2. Considering the risk of infected individuals to develop high morbidity and mortality diseases, it would be important to implement public health policies aimed at stopping transmission of these viruses in this municipality.

Citing Articles

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HTLV-1 and HTLV-2 infections in patients with endemic mycoses in São Paulo, Brazil: A cross-sectional, observational study.

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References

Alves F, Campos K, Lemos M, Moreira R, Caterino-de-Araujo A . Hepatitis C viral load in HCV-monoinfected and HCV/HIV-1-, HCV/HTLV-1/-2-, and HCV/HIV/HTLV-1/-2-co-infected patients from São Paulo, Brazil. Braz J Infect Dis. 2018; 22(2):123-128. PMC: 9428188. DOI: 10.1016/j.bjid.2018.03.002. View

Ishak R, de Oliveira Guimaraes Ishak M, Vallinoto A . The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil. Retrovirology. 2020; 17(1):4. PMC: 7023703. DOI: 10.1186/s12977-020-0512-z. View

Bandeira L, Puga M, Weis-Torres S, Rezende G, Domingos J, Tanaka T . Human T-cell leukemia virus type 1 infection among Japanese immigrants and their descendants living in Southeast Brazil: A call for preventive and control responses. PLoS Negl Trop Dis. 2021; 15(2):e0009066. PMC: 7864455. DOI: 10.1371/journal.pntd.0009066. View

Castro L, de Rezende G, Pires Fernandes F, Bandeira L, Moreira Puga M, Ortiz Tanaka T . Human T cell lymphotropic virus type 1 infection among men who have sex with men in Central Brazil. Braz J Infect Dis. 2018; 22(6):472-476. PMC: 9425634. DOI: 10.1016/j.bjid.2018.11.003. View

Carneiro-Proietti A, Catalan-Soares B, Castro-Costa C, Murphy E, Sabino E, Hisada M . HTLV in the Americas: challenges and perspectives. Rev Panam Salud Publica. 2006; 19(1):44-53. DOI: 10.1590/s1020-49892006000100007. View

Nunes D, Boa-Sorte N, Grassi M, Taylor G, Teixeira M, Barreto M . HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil. PLoS One. 2017; 12(2):e0171303. PMC: 5291389. DOI: 10.1371/journal.pone.0171303. View

Gotuzzo E, Moody J, Verdonck K, Cabada M, Gonzalez E, Van Dooren S . Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis. Rev Panam Salud Publica. 2007; 22(4):223-30. DOI: 10.1590/s1020-49892007000900001. View

Caterino-de-Araujo A, Sacchi C, Goncalves M, Campos K, Magri M, Alencar W . Short Communication: Current Prevalence and Risk Factors Associated with Human T Lymphotropic Virus Type 1 and Human T Lymphotropic Virus Type 2 Infections Among HIV/AIDS Patients in São Paulo, Brazil. AIDS Res Hum Retroviruses. 2014; 31(5):543-9. PMC: 4426329. DOI: 10.1089/AID.2014.0287. View

Kozlowski A, Matos M, Carneiro M, Lopes C, Teles S, Vicente C . SEROPREVALENCE OF HTLV IN A POPULATION OF HIV1-INFECTED PATIENTS IN MIDWESTERN BRAZIL. Rev Inst Med Trop Sao Paulo. 2016; 58:80. PMC: 5096634. DOI: 10.1590/S1678-9946201658080. View

10.

Guimaraes de Souza V, Martins M, Barbara de Freitas Carneiro-Proietti A, Januario J, Ladeira R, Silva C . High prevalence of HTLV-1 and 2 viruses in pregnant women in São Luis, state of Maranhão, Brazil. Rev Soc Bras Med Trop. 2012; 45(2):159-62. DOI: 10.1590/s0037-86822012000200004. View

11.

de Lima W, Martins Esteves F, Torres M, Pires E . Prevalence of human T-cell lymphotropic virus types 1 and 2 in blood donors of the Caruaru Blood Center (Hemope). Rev Bras Hematol Hemoter. 2013; 35(4):268-71. PMC: 3789432. DOI: 10.5581/1516-8484.20130061. View

12.

Paiva A, Assone T, Haziot M, Smid J, Fonseca L, Luiz O . Risk factors associated with HTLV-1 vertical transmission in Brazil: longer breastfeeding, higher maternal proviral load and previous HTLV-1-infected offspring. Sci Rep. 2018; 8(1):7742. PMC: 5958084. DOI: 10.1038/s41598-018-25939-y. View

13.

de Araujo A, Casseb J, Neitzert E, De Souza M, Mammano F, Del Mistro A . HTLV-I and HTLV-II infections among HIV-1 seropositive patients in Sao Paulo, Brazil. Eur J Epidemiol. 1994; 10(2):165-71. DOI: 10.1007/BF01730366. View

14.

Galetto L, Lunge V, Beria J, Tietzmann D, Stein A, Simon D . Short communication: Prevalence and risk factors for human T cell lymphotropic virus infection in Southern Brazilian HIV-positive patients. AIDS Res Hum Retroviruses. 2014; 30(9):907-11. DOI: 10.1089/AID.2013.0210. View

15.

Gessain A, Cassar O . Epidemiological Aspects and World Distribution of HTLV-1 Infection. Front Microbiol. 2012; 3:388. PMC: 3498738. DOI: 10.3389/fmicb.2012.00388. View

16.

Bangham C . Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis. Annu Rev Immunol. 2017; 36:43-71. DOI: 10.1146/annurev-immunol-042617-053222. View

17.

Catalan-Soares B, Carneiro-Proietti A, Proietti F . Heterogeneous geographic distribution of human T-cell lymphotropic viruses I and II (HTLV-I/II): serological screening prevalence rates in blood donors from large urban areas in Brazil. Cad Saude Publica. 2005; 21(3):926-31. DOI: 10.1590/s0102-311x2005000300027. View

18.

Pereira F, de Almeida M, Santos F, Carreiro R, Galvao-Castro B, Grassi M . Distribution of Human T-Lymphotropic Virus (HTLV) and Hepatitis C Co-infection in Bahia, Brazil. PLoS One. 2020; 15(7):e0223087. PMC: 7373273. DOI: 10.1371/journal.pone.0223087. View

19.

Martin F, Tagaya Y, Gallo R . Time to eradicate HTLV-1: an open letter to WHO. Lancet. 2018; 391(10133):1893-1894. DOI: 10.1016/S0140-6736(18)30974-7. View

20.

Poiesz B, Ruscetti F, Gazdar A, Bunn P, Minna J, Gallo R . Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980; 77(12):7415-9. PMC: 350514. DOI: 10.1073/pnas.77.12.7415. View