The Role of GPR56/ADGRG1 in Health and Disease

Overview

Journal Biomed J

Publisher Elsevier

Specialty General Medicine

Date 2021 Oct 16

PMID 34654683

Citations 19

Authors

Abhishek Kumar Singh

Hsi-Hsien Lin

Affiliations

Soon will be listed here.

Abstract

GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.

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