Gastrointestinal Microbiome and Gluten in Celiac Disease

Overview

Journal Ann Med

Publisher Informa Healthcare

Specialty General Medicine

Date 2021 Oct 14

PMID 34647492

Citations 15

Authors

Xingxing Wu

Lin Qian

Kexin Liu

Jing Wu

Zhaowei Shan

Affiliations

Soon will be listed here.

Abstract

Coeliac disease (CD), also known as gluten sensitive enteropathy, is an autoimmune intestinal disease induced by gluten in genetically susceptible individuals. Gluten is a common ingredient in daily diet and is one of the main environmental factors to induce coeliac disease. Adhering to gluten free diet (GFD) is an effective method for treating CD. Microbiota plays an extremely important role in maintaining human health, and diet is the main factor to regulate the composition and function of gut microbiota. Recent studies have shown that gluten metabolism is closely related to gastrointestinal tract (GIT) microbiota. With the increasing prevalence of coeliac disease, there is a need for alternative treatments to GFD. In this review, biological medication of gluten, relationship between gluten and gut microflora, effect of GFD on GIT microflora, and effect of probiotics on CD were reviewed. By analysing the research progress on relationship between gluten and gastrointestinal microbiome in coeliac disease, this review tried to explore the prospective and potential mechanism of microecological agents in treating coeliac disease.

Citing Articles

The Role of Gluten in the Development of Autoimmune Thyroid Diseases: A Narrative Review.

Esfahani K, Asri N, Mahmoudi Ghehsareh M, Rezaei-Tavirani M, Jahani-Sherafat S, Rostami-Nejad M Int J Endocrinol Metab. 2025; 22(3):e153730.

PMID: 40065831 PMC: 11892518. DOI: 10.5812/ijem-153730.

Celiac Disease: Beyond Diet and Food Awareness.

Herrera-Quintana L, Navajas-Porras B, Vazquez-Lorente H, Hinojosa-Nogueira D, Corrales-Borrego F, Lopez-Garzon M Foods. 2025; 14(3).

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Assessment of salivary microbiota profile as a potential diagnostic tool for pediatric celiac disease.

Noruzpour A, Gholam-Mostafaei F, Azizmohammad Looha M, Dabiri H, Ahmadipour S, Rouhani P Sci Rep. 2024; 14(1):16712.

PMID: 39030381 PMC: 11271620. DOI: 10.1038/s41598-024-67677-4.

How the Microbiota May Affect Celiac Disease and What We Can Do.

Matera M, Guandalini S Nutrients. 2024; 16(12).

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Celiac Disease: The Importance of Studying the Duodenal Mucosa-Associated Microbiota.

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PMID: 38892582 PMC: 11174386. DOI: 10.3390/nu16111649.

References

Lebwohl B, Sanders D, Green P . Coeliac disease. Lancet. 2017; 391(10115):70-81. DOI: 10.1016/S0140-6736(17)31796-8. View

Reddel S, Putignani L, Del Chierico F . The Impact of Low-FODMAPs, Gluten-Free, and Ketogenic Diets on Gut Microbiota Modulation in Pathological Conditions. Nutrients. 2019; 11(2). PMC: 6413021. DOI: 10.3390/nu11020373. View

Sommer F, Backhed F . The gut microbiota--masters of host development and physiology. Nat Rev Microbiol. 2013; 11(4):227-38. DOI: 10.1038/nrmicro2974. View

Shang L, Deng D, Buskermolen J, Janus M, Krom B, Roffel S . Multi-species oral biofilm promotes reconstructed human gingiva epithelial barrier function. Sci Rep. 2018; 8(1):16061. PMC: 6207751. DOI: 10.1038/s41598-018-34390-y. View

Caminero A, McCarville J, Galipeau H, Deraison C, Bernier S, Constante M . Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. Nat Commun. 2019; 10(1):1198. PMC: 6416356. DOI: 10.1038/s41467-019-09037-9. View

Herran A, Perez-Andres J, Caminero A, Nistal E, Vivas S, Ruiz de Morales J . Gluten-degrading bacteria are present in the human small intestine of healthy volunteers and celiac patients. Res Microbiol. 2017; 168(7):673-684. DOI: 10.1016/j.resmic.2017.04.008. View

Shan L, Qiao S, Arentz-Hansen H, Molberg O, Gray G, Sollid L . Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. J Proteome Res. 2005; 4(5):1732-41. PMC: 1343496. DOI: 10.1021/pr050173t. View

Sanz Y . Microbiome and Gluten. Ann Nutr Metab. 2015; 67 Suppl 2:28-41. DOI: 10.1159/000440991. View

Davila A, Blachier F, Gotteland M, Andriamihaja M, Benetti P, Sanz Y . Re-print of "Intestinal luminal nitrogen metabolism: role of the gut microbiota and consequences for the host". Pharmacol Res. 2013; 69(1):114-26. DOI: 10.1016/j.phrs.2013.01.003. View

10.

Bonder M, Tigchelaar E, Cai X, Trynka G, Cenit M, Hrdlickova B . The influence of a short-term gluten-free diet on the human gut microbiome. Genome Med. 2016; 8(1):45. PMC: 4841035. DOI: 10.1186/s13073-016-0295-y. View

11.

Primec M, Klemenak M, Di Gioia D, Aloisio I, Bozzi Cionci N, Quagliariello A . Clinical intervention using Bifidobacterium strains in celiac disease children reveals novel microbial modulators of TNF-α and short-chain fatty acids. Clin Nutr. 2018; 38(3):1373-1381. DOI: 10.1016/j.clnu.2018.06.931. View

12.

Helmerhorst E, Zamakhchari M, Schuppan D, Oppenheim F . Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity. PLoS One. 2010; 5(10):e13264. PMC: 2952584. DOI: 10.1371/journal.pone.0013264. View

13.

. Structure, function and diversity of the healthy human microbiome. Nature. 2012; 486(7402):207-14. PMC: 3564958. DOI: 10.1038/nature11234. View

14.

Cagno R, De Angelis M, De Pasquale I, Ndagijimana M, Vernocchi P, Ricciuti P . Duodenal and faecal microbiota of celiac children: molecular, phenotype and metabolome characterization. BMC Microbiol. 2011; 11:219. PMC: 3206437. DOI: 10.1186/1471-2180-11-219. View

15.

Caminero A, Herran A, Nistal E, Perez-Andres J, Vaquero L, Vivas S . Diversity of the cultivable human gut microbiome involved in gluten metabolism: isolation of microorganisms with potential interest for coeliac disease. FEMS Microbiol Ecol. 2014; 88(2):309-19. DOI: 10.1111/1574-6941.12295. View

16.

Bernardo D, Garrote J, Nadal I, Leon A, Calvo C, Fernandez-Salazar L . Is it true that coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa. Gut. 2009; 58(6):886-7. DOI: 10.1136/gut.2008.167296. View

17.

Lockhart P, Durack D . Oral microflora as a cause of endocarditis and other distant site infections. Infect Dis Clin North Am. 1999; 13(4):833-50, vi. DOI: 10.1016/s0891-5520(05)70111-2. View

18.

Piombino P, Genovese A, Esposito S, Moio L, Cutolo P, Chambery A . Saliva from obese individuals suppresses the release of aroma compounds from wine. PLoS One. 2014; 9(1):e85611. PMC: 3899019. DOI: 10.1371/journal.pone.0085611. View

19.

Allen B, Orfila C . The Availability and Nutritional Adequacy of Gluten-Free Bread and Pasta. Nutrients. 2018; 10(10). PMC: 6213709. DOI: 10.3390/nu10101370. View

20.

Schmidt T, Hayward M, Coelho L, Li S, Costea P, Voigt A . Extensive transmission of microbes along the gastrointestinal tract. Elife. 2019; 8. PMC: 6424576. DOI: 10.7554/eLife.42693. View