Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Oct 14

PMID 34646821

Citations 30

Authors

Ebrahim Balandeh

Kimia Mohammadshafie

Yaser Mahmoudi

Mohammad Hossein Pourhanifeh

Ali Rajabi

Zahra Razaghi Bahabadi

Amir Hossein Mohammadi

Neda Rahimian

Michael R Hamblin

Hamed Mirzaei

Affiliations

Soon will be listed here.

Abstract

One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in or forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways.

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