Cell-Based Transplantation Versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2021 Oct 14

PMID 34646323

Citations 7

Authors

Geraldine M Ahmed

Eman A Abouauf

Nermeen AbuBakr

Asmaa M Fouad

Christof E Dorfer

Karim M Fawzy El-Sayed

Affiliations

Soon will be listed here.

Abstract

Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were introduced for a fully functional pulp-dentin complex regeneration, namely, cell-based (cell transplantation) and cell homing (through revascularization or homing by injection of stem cells in situ or intravenously) therapies, with each demonstrating advantages as well as drawbacks, especially in clinical application. The present review is aimed at elaborating on these two techniques in the treatment of irreversibly inflamed or necrotic pulp, which is aimed at regenerating a fully functional pulp-dentin complex.

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