» Articles » PMID: 34646109

Loneliness and Social Isolation As Risk Factors: The Power of Social Connection in Prevention

Overview
Publisher Sage Publications
Date 2021 Oct 14
PMID 34646109
Citations 29
Authors
Affiliations
Soon will be listed here.
Abstract

Social isolation and loneliness were already pressing concerns prior to the pandemic, but recent trends suggest a potential broadening of this public health crisis. Social connections have potent influences on health and longevity, and lacking social connection qualifies as a risk factor for premature mortality. However, social factors are often overlooked in medical and healthcare practice. There is also evidence documenting effects on biomarkers and health-relevant behaviors, as well as more proximal means social connection influences physical health. A recent National Academy of Science consensus committee report provides recommendations for how this evidence can inform medical and healthcare. Clinicians play an important role in assessing, preventing, and mitigating the adverse effects of social isolation and loneliness.

Citing Articles

Social support in a large general population sample over the course of six years.

Hinz A, Esser P, Richter D, Schonfelder A, Glaesmer H, Lehmann-Laue A Sci Rep. 2025; 15(1):6405.

PMID: 39984578 PMC: 11845683. DOI: 10.1038/s41598-025-90703-y.


Social connections are differentially related to perceived and physiological age acceleration amongst older adults.

Fancourt D, Bloomberg M, Steptoe A medRxiv. 2025; .

PMID: 39973988 PMC: 11838645. DOI: 10.1101/2025.02.03.25320261.


Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes.

Pangrazzi L, Meryk A Biology (Basel). 2025; 14(1).

PMID: 39857248 PMC: 11760833. DOI: 10.3390/biology14010017.


Increased arterial stiffness is associated with poorer social cognition in older age.

Grainger S, Bailey T, Vear N, Mead J, Bourdaniotis X, Coombes J Sci Rep. 2025; 15(1):2285.

PMID: 39833420 PMC: 11746973. DOI: 10.1038/s41598-025-86423-y.


Does internet use promote the health of empty-nest older adults in rural China? The mediating role of social participation using a propensity score matching approach.

Shen L, Zheng Y, Wang M, Pan H, Jian W, Yang X Front Public Health. 2024; 12:1436525.

PMID: 39651475 PMC: 11621002. DOI: 10.3389/fpubh.2024.1436525.


References
1.
Studdert D, Zhang Y, Swanson S, Prince L, Rodden J, Holsinger E . Handgun Ownership and Suicide in California. N Engl J Med. 2020; 382(23):2220-2229. DOI: 10.1056/NEJMsa1916744. View

2.
Broadbent E, Koschwanez H . The psychology of wound healing. Curr Opin Psychiatry. 2011; 25(2):135-40. DOI: 10.1097/YCO.0b013e32834e1424. View

3.
McClintock M, Dale W, Laumann E, Waite L . Empirical redefinition of comprehensive health and well-being in the older adults of the United States. Proc Natl Acad Sci U S A. 2016; 113(22):E3071-80. PMC: 4896706. DOI: 10.1073/pnas.1514968113. View

4.
Kotwal A, Holt-Lunstad J, Newmark R, Cenzer I, Smith A, Covinsky K . Social Isolation and Loneliness Among San Francisco Bay Area Older Adults During the COVID-19 Shelter-in-Place Orders. J Am Geriatr Soc. 2020; 69(1):20-29. PMC: 7536935. DOI: 10.1111/jgs.16865. View

5.
Creswell J, Irwin M, Burklund L, Lieberman M, Arevalo J, Ma J . Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav Immun. 2012; 26(7):1095-101. PMC: 3635809. DOI: 10.1016/j.bbi.2012.07.006. View