Mechanobiology of the Female Reproductive System

Overview

Journal Reprod Med Biol

Specialty Biology

Date 2021 Oct 14

PMID 34646066

Citations 15

Authors

Sachiko Matsuzaki

Affiliations

Soon will be listed here.

Abstract

Background: Mechanobiology in the field of human female reproduction has been extremely challenging technically and ethically.

Methods: The present review provides the current knowledge on mechanobiology of the female reproductive system. This review focuses on the early phases of reproduction from oocyte development to early embryonic development, with an emphasis on current progress.

Main Findings Results: Optimal, well-controlled mechanical cues are required for female reproductive system physiology. Many important questions remain unanswered; whether and how mechanical imbalances among the embryo, decidua, and uterine muscle contractions affect early human embryonic development, whether the biomechanical properties of oocytes/embryos are potential biomarkers for selecting high-quality oocytes/embryos, whether mechanical properties differ between the two major compartments of the ovary (cortex and medulla) in normally ovulating human ovaries, whether durotaxis is involved in several processes in addition to embryonic development. Progress in mechanobiology is dependent on development of technologies that enable precise physical measurements.

Conclusion: More studies are needed to understand the roles of forces and changes in the mechanical properties of female reproductive system physiology. Recent and future technological advancements in mechanobiology research will help us understand the role of mechanical forces in female reproductive system disorders/diseases.

Citing Articles

Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.

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Actomyosin contraction in the follicular epithelium provides the major mechanical force for follicle rupture during ovulation.

Cho S, Li W, Beard A, Jackson J, Kiernan R, Hoshino K Proc Natl Acad Sci U S A. 2024; 121(39):e2407083121.

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Region-Specific Decellularization of Porcine Uterine Tube Extracellular Matrix: A New Approach for Reproductive Tissue-Engineering Applications.

Almeida G, da Silva R, Gibin M, Gonzaga V, Dos Santos H, Igleisa R Biomimetics (Basel). 2024; 9(7).

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In Vitro Culture of Mammalian Embryos: Is There Room for Improvement?.

Gualtieri R, De Gregorio V, Candela A, Travaglione A, Genovese V, Barbato V Cells. 2024; 13(12.

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References

Isachenko V, Maettner R, Sterzik K, Strehler E, Kreinberg R, Hancke K . In-vitro culture of human embryos with mechanical micro-vibration increases implantation rates. Reprod Biomed Online. 2011; 22(6):536-44. DOI: 10.1016/j.rbmo.2011.02.006. View

Chan C, Costanzo M, Ruiz-Herrero T, Monke G, Petrie R, Bergert M . Hydraulic control of mammalian embryo size and cell fate. Nature. 2019; 571(7763):112-116. DOI: 10.1038/s41586-019-1309-x. View

Abbas Y, Turco M, Burton G, Moffett A . Investigation of human trophoblast invasion in vitro. Hum Reprod Update. 2020; 26(4):501-513. PMC: 7473396. DOI: 10.1093/humupd/dmaa017. View

DaSilva-Arnold S, James J, Al-Khan A, Zamudio S, Illsley N . Differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition. Placenta. 2015; 36(12):1412-8. DOI: 10.1016/j.placenta.2015.10.013. View

Gjorevski N, Boghaert E, Nelson C . Regulation of Epithelial-Mesenchymal Transition by Transmission of Mechanical Stress through Epithelial Tissues. Cancer Microenviron. 2011; 5(1):29-38. PMC: 3343202. DOI: 10.1007/s12307-011-0076-5. View

Cui Y, Hameed F, Yang B, Lee K, Pan C, Park S . Cyclic stretching of soft substrates induces spreading and growth. Nat Commun. 2015; 6:6333. PMC: 4346610. DOI: 10.1038/ncomms7333. View

Basara G, Gulberk Ozcebe S, Ellis B, Zorlutuna P . Tunable Human Myocardium Derived Decellularized Extracellular Matrix for 3D Bioprinting and Cardiac Tissue Engineering. Gels. 2021; 7(2). PMC: 8293197. DOI: 10.3390/gels7020070. View

Boretto M, Cox B, Noben M, Hendriks N, Fassbender A, Roose H . Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability. Development. 2017; 144(10):1775-1786. DOI: 10.1242/dev.148478. View

Alzamil L, Nikolakopoulou K, Turco M . Organoid systems to study the human female reproductive tract and pregnancy. Cell Death Differ. 2020; 28(1):35-51. PMC: 7852529. DOI: 10.1038/s41418-020-0565-5. View

10.

Sarvazyan A, Hall T, Urban M, Fatemi M, Aglyamov S, Garra B . AN OVERVIEW OF ELASTOGRAPHY - AN EMERGING BRANCH OF MEDICAL IMAGING. Curr Med Imaging Rev. 2012; 7(4):255-282. PMC: 3269947. DOI: 10.2174/157340511798038684. View

11.

ESPEY L, Lipner H . MEASUREMENTS OF INTRAFOLLICULAR PRESSURES IN THE RABBIT OVARY. Am J Physiol. 1963; 205:1067-72. DOI: 10.1152/ajplegacy.1963.205.6.1067. View

12.

Chumduri C, Turco M . Organoids of the female reproductive tract. J Mol Med (Berl). 2021; 99(4):531-553. PMC: 8026429. DOI: 10.1007/s00109-020-02028-0. View

13.

Priel E, Priel T, Szaingurten-Solodkin I, Wainstock T, Perets Y, Zeadna A . Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment. Sci Rep. 2020; 10(1):14066. PMC: 7443135. DOI: 10.1038/s41598-020-70739-y. View

14.

Jiang X, Asbach P, Streitberger K, Thomas A, Hamm B, Braun J . In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix. Eur Radiol. 2014; 24(12):3025-33. DOI: 10.1007/s00330-014-3305-8. View

15.

Korotkevich E, Niwayama R, Courtois A, Friese S, Berger N, Buchholz F . The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo. Dev Cell. 2017; 40(3):235-247.e7. PMC: 5300053. DOI: 10.1016/j.devcel.2017.01.006. View

16.

Harada M, Osuga Y, Hirota Y, Koga K, Morimoto C, Hirata T . Mechanical stretch stimulates interleukin-8 production in endometrial stromal cells: possible implications in endometrium-related events. J Clin Endocrinol Metab. 2004; 90(2):1144-8. DOI: 10.1210/jc.2004-1089. View

17.

Yanez L, Han J, Behr B, Pera R, Camarillo D . Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization. Nat Commun. 2016; 7:10809. PMC: 4770082. DOI: 10.1038/ncomms10809. View

18.

Ihnatovych I, Hu W, Martin J, Fazleabas A, de Lanerolle P, Strakova Z . Increased phosphorylation of myosin light chain prevents in vitro decidualization. Endocrinology. 2007; 148(7):3176-84. DOI: 10.1210/en.2006-1673. View

19.

Li X, Sun Q, Li Q, Kawazoe N, Chen G . Functional Hydrogels With Tunable Structures and Properties for Tissue Engineering Applications. Front Chem. 2018; 6:499. PMC: 6204355. DOI: 10.3389/fchem.2018.00499. View

20.

Uhler C, Shivashankar G . Regulation of genome organization and gene expression by nuclear mechanotransduction. Nat Rev Mol Cell Biol. 2017; 18(12):717-727. DOI: 10.1038/nrm.2017.101. View