Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life

Overview

Journal J Neurogastroenterol Motil

Date 2021 Oct 13

PMID 34642281

Citations 9

Authors

Sayuri Yamamoto

Yurika Kawamura

Kazuhiro Yamamoto

Yoshiharu Yamaguchi

Yasuhiro Tamura

Shinya Izawa

Hiroaki Nakagawa

Yoshinori Wakita

Yasutaka Hijikata

Masahide Ebi

Yasushi Funaki

Wataru Ohashi

Naotaka Ogasawara

Makoto Sasaki

Masato Maekawa

Kunio Kasugai

Affiliations

Soon will be listed here.

Abstract

Background/aims: Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population.

Methods: This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included correlations between quality of life (QOL) and mood, medical, lifestyle, and sleep factors.

Results: The proportion of participants with BSFS category 4 (normal stool) was significantly higher in the good sleep group ( < 0.001). Sleep disturbance ( < 0.05), sleep quality, and duration, use of hypnotic medication, and daytime dysfunction of PSQI (all < 0.001) significantly correlated with poor sleep. In the poor sleep group, QOL was significantly worse and anxiety and depression levels were significantly higher (all < 0.001) compared with the good sleep group. Anemia and smoking (both < 0.05), recent body weight increases, and poor eating habits (all P < 0.001) were significantly higher in the poor sleep group. Male sex, onset associated with change in frequency of stools, sensation of incomplete evacuation for at least 25% of defecations, and manual maneuvers to facilitate at least 25% of defecations correlated with poor sleep.

Conclusions: Subjects with constipation and poor sleep experienced severe symptoms and had poor QOL. These data support the need for a multifocal treatment approach, including lifestyle advice and pharmacotherapy.

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