Nanofiber-based Systems Intended for Diabetes

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2021 Oct 13

PMID 34641920

Citations 13

Authors

Hassan Maleki

Kamyar Khoshnevisan

Sayed Mahmoud Sajjadi-Jazi

Hadi Baharifar

Maryam Doostan

Nazanin Khoshnevisan

Farshad Sharifi

Affiliations

Soon will be listed here.

Abstract

Diabetic mellitus (DM) is the most communal metabolic disease resulting from a defect in insulin secretion, causing hyperglycemia by promoting the progressive destruction of pancreatic β cells. This autoimmune disease causes many severe disorders leading to organ failure, lower extremity amputations, and ultimately death. Modern delivery systems e.g., nanofiber (NF)-based systems fabricated by natural and synthetic or both materials to deliver therapeutics agents and cells, could be the harbinger of a new era to obviate DM complications. Such delivery systems can effectively deliver macromolecules (insulin) and small molecules. Besides, NF scaffolds can provide an ideal microenvironment to cell therapy for pancreatic β cell transplantation and pancreatic tissue engineering. Numerous studies indicated the potential usage of therapeutics/cells-incorporated NF mats to proliferate/regenerate/remodeling the structural and functional properties of diabetic skin ulcers. Thus, we intended to discuss the aforementioned features of the NF system for DM complications in detail.

Citing Articles

Multifunctional combined drug-loaded nanofibrous dressings with anti-inflammatory, antioxidant stress and microenvironment improvement for diabetic wounds.

Ju Y, Luo Y, Li R, Zhang W, Ge Y, Tang J RSC Adv. 2024; 14(40):29606-29623.

PMID: 39297039 PMC: 11409454. DOI: 10.1039/d4ra04860a.

A core-shell-type nanosystem promotes diabetic wound healing through Photothermal-responsive release of transforming growth factor β.

Hou J, Jie J, Wei X, Shen X, Zhao Q, Chai X J Nanobiotechnology. 2024; 22(1):449.

PMID: 39080658 PMC: 11287882. DOI: 10.1186/s12951-024-02675-2.

Preparation and Characterization of Chitosan Nanofiber: Kinetic Studies and Enhancement of Insulin Delivery System.

Fouad S, Ismail A, Abdel Rafea M, Abu Saied M, El-Dissouky A Nanomaterials (Basel). 2024; 14(11).

PMID: 38869577 PMC: 11173695. DOI: 10.3390/nano14110952.

Advanced multifunctional hydrogels for diabetic foot ulcer healing: Active substances and biological functions.

Li Y, Leng Y, Liu Y, Zhong J, Li J, Zhang S J Diabetes. 2024; 16(4):e13537.

PMID: 38599855 PMC: 11006623. DOI: 10.1111/1753-0407.13537.

and extracts co-loaded polyvinyl alcohol and chitosan electrospun nanofibers for tackling infection and wound healing promotion.

Maleki H, Doostan M, Khoshnevisan K, Baharifar H, Maleki S, Fatahi M Heliyon. 2024; 10(1):e23719.

PMID: 38223730 PMC: 10784172. DOI: 10.1016/j.heliyon.2023.e23719.

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