Effects of Wine Components in Inflammatory Bowel Diseases

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Oct 13

PMID 34641434

Citations 7

Authors

Josip Vrdoljak

Marko Kumric

Tina Ticinovic Kurir

Ivan Males

Dinko Martinovic

Marino Vilovic

Josko Bozic

Affiliations

Soon will be listed here.

Abstract

With the rising prevalence of Inflammatory bowel disease (IBD) worldwide, and the rising cost of treatment with novel biological drugs, there is an increasing interest in various diets and natural foods as a potential way to control/modulate IBD. As recent data indicates that diet can modify the metabolic responses essential for the resolution of inflammation, and as wine compounds have been shown to provide substantial anti-inflammatory effect, in this review we aimed to discuss the current evidence concerning the impact of biological compounds present in wine on IBD. A number of preclinical studies brought forth strong evidence on the mechanisms by which molecules in wine, such as resveratrol or piceatannol, provide their anti-inflammatory, anti-oxidative, anti-tumor, and microbiota-modulation effects. However, concerning the effects of alcohol, it is still unclear how the amount of ethanol ingested within the framework of moderate wine consumption (1-2 glasses a day) affects patients with IBD, as human studies regarding the effects of wine on patients with IBD are scarce. Nevertheless, available evidence justifies the conductance of large-scale RCT trials on human subjects that will finally elucidate whether wine can offer real benefits to the IBD population.

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References

Wark G, Samocha-Bonet D, Ghaly S, Danta M . The Role of Diet in the Pathogenesis and Management of Inflammatory Bowel Disease: A Review. Nutrients. 2021; 13(1). PMC: 7823614. DOI: 10.3390/nu13010135. View

Roupe K, Remsberg C, Yanez J, Davies N . Pharmacometrics of stilbenes: seguing towards the clinic. Curr Clin Pharmacol. 2008; 1(1):81-101. DOI: 10.2174/157488406775268246. View

White B, Piovezani Ramos G, Kane S . The Impact of Alcohol in Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2021; 28(3):466-473. DOI: 10.1093/ibd/izab089. View

Knutson D, Greenberg G, Cronau H . Management of Crohn's disease--a practical approach. Am Fam Physician. 2003; 68(4):707-14. View

Zivkovic P, Matetic A, Tadin Hadjina I, Rusic D, Vilovic M, Supe-Domic D . Serum Catestatin Levels and Arterial Stiffness Parameters Are Increased in Patients with Inflammatory Bowel Disease. J Clin Med. 2020; 9(3). PMC: 7141110. DOI: 10.3390/jcm9030628. View

Sears B, Saha A . Dietary Control of Inflammation and Resolution. Front Nutr. 2021; 8:709435. PMC: 8382877. DOI: 10.3389/fnut.2021.709435. View

Rodriguez-Ramiro I, Ramos S, Bravo L, Goya L, Martin M . Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress. Eur J Nutr. 2011; 51(7):881-92. DOI: 10.1007/s00394-011-0269-1. View

Dolara P, Luceri C, De Filippo C, Femia A, Giovannelli L, Caderni G . Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutat Res. 2005; 591(1-2):237-46. DOI: 10.1016/j.mrfmmm.2005.04.022. View

Dubinkina V, Tyakht A, Odintsova V, Yarygin K, Kovarsky B, Pavlenko A . Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease. Microbiome. 2017; 5(1):141. PMC: 5645934. DOI: 10.1186/s40168-017-0359-2. View

10.

Kwon G, Jung J, Song H, Woo E, Jun J, Kim J . Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling. J Nutr Biochem. 2011; 23(3):228-38. DOI: 10.1016/j.jnutbio.2010.11.019. View

11.

Trichopoulou A, Martinez-Gonzalez M, Tong T, Forouhi N, Khandelwal S, Prabhakaran D . Definitions and potential health benefits of the Mediterranean diet: views from experts around the world. BMC Med. 2014; 12:112. PMC: 4222885. DOI: 10.1186/1741-7015-12-112. View

12.

Nicod N, Chiva-Blanch G, Giordano E, Davalos A, Parker R, Visioli F . Green tea, cocoa, and red wine polyphenols moderately modulate intestinal inflammation and do not increase high-density lipoprotein (HDL) production. J Agric Food Chem. 2014; 62(10):2228-32. DOI: 10.1021/jf500348u. View

13.

Li R, Kim M, Sandhu A, Gao C, Gu L . Muscadine Grape (Vitis rotundifolia) or Wine Phytochemicals Reduce Intestinal Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis. J Agric Food Chem. 2017; 65(4):769-776. DOI: 10.1021/acs.jafc.6b03806. View

14.

Longobardi T, Jacobs P, Bernstein C . Work losses related to inflammatory bowel disease in the United States: results from the National Health Interview Survey. Am J Gastroenterol. 2003; 98(5):1064-72. DOI: 10.1111/j.1572-0241.2003.07285.x. View

15.

Martin A, Villegas I, Sanchez-Hidalgo M, Alarcon de la Lastra C . The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. Br J Pharmacol. 2006; 147(8):873-85. PMC: 1760707. DOI: 10.1038/sj.bjp.0706469. View

16.

Shi Y, Zhou J, Jiang B, Miao M . Resveratrol and inflammatory bowel disease. Ann N Y Acad Sci. 2017; 1403(1):38-47. DOI: 10.1111/nyas.13426. View

17.

Deiana M, Loru D, Incani A, Rosa A, Atzeri A, Melis M . Wine extracts from Sardinian grape varieties attenuate membrane oxidative damage in Caco-2 cell monolayers. Food Chem. 2013; 134(4):2105-13. DOI: 10.1016/j.foodchem.2012.04.014. View

18.

Park K, Ehrlich O, Allen J, Meadows P, Szigethy E, Henrichsen K . The Cost of Inflammatory Bowel Disease: An Initiative From the Crohn's & Colitis Foundation. Inflamm Bowel Dis. 2019; 26(1):1-10. PMC: 7534391. DOI: 10.1093/ibd/izz104. View

19.

Wang Y, Yang X, Wang L, Cui M, Cai Y, Li X . Effects of proanthocyanidins from grape seed on treatment of recurrent ulcerative colitis in rats. Can J Physiol Pharmacol. 2010; 88(9):888-98. DOI: 10.1139/y10-071. View

20.

Cianciulli A, Calvello R, Cavallo P, Dragone T, Carofiglio V, Panaro M . Modulation of NF-κB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE2 production and COX-2 expression. Toxicol In Vitro. 2012; 26(7):1122-8. DOI: 10.1016/j.tiv.2012.06.015. View