Regioselective C-H Functionalization of the Six-Membered Ring of the 6,5-Fused Heterocyclic Systems: An Overview

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Oct 13

PMID 34641306

Citations 2

Authors

Soukaina Faarasse

Nabil El Brahmi

Gerald Guillaumet

Said El Kazzouli

Affiliations

Soon will be listed here.

Abstract

The regioselective C-H functionalization of the five-membered ring of the 6,5-fused heterocyclic systems is nowadays well documented due to its high reactivity compared to the six-membered ring. So, developing new procedures of C-H functionalization of the six-membered ring "by thinking out of the box" is extremely challenging, which explains the limited number of reports published to date. This review paper aims to highlight advances achieved in this emerging chemistry research and discusses recently reported methods.

Citing Articles

Regio- and Chemoselective Palladium-Catalyzed Additive-Free Direct C─H Functionalization of Heterocycles with Chloroaryl Triflates Using Pyrazole-Alkyl Phosphine Ligands.

Gu C, So C Adv Sci (Weinh). 2024; 11(21):e2309192.

PMID: 38482750 PMC: 11151040. DOI: 10.1002/advs.202309192.

Unlocking the Potential of Deep Eutectic Solvents for C-H Activation and Cross-Coupling Reactions: A Review.

El Baraka Y, Hamdoun G, El Brahmi N, El Kazzouli S Molecules. 2023; 28(12).

PMID: 37375204 PMC: 10302773. DOI: 10.3390/molecules28124651.

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