Assessing Countermeasures During a Hepatitis A Virus Outbreak Among Men Who Have Sex with Men

Overview

Journal Theor Biol Med Model

Publisher Biomed Central

Date 2021 Oct 12

PMID 34635146

Citations 1

Authors

Ryohei Saito

Akifumi Imamura

Hiroshi Nishiura

Affiliations

Soon will be listed here.

Abstract

Background: A hepatitis A epidemic occurred among men who have sex with men (MSM) in Japan in 2017-2018. In this study, we employ a parsimonious mathematical model to epidemiologically investigate the dynamics of infection, aiming to evaluate the effectiveness of campaign-based interventions among MSM to raise awareness of the situation.

Methods: A mathematical model describing a mixture of human-to-human transmission and environmental transmission was fitted to surveillance data. Taking seasonally varying environmental transmission into account, we estimated the reproduction number of hepatitis A virus during the course of epidemic, and, especially, the abrupt decline in this reproduction number following campaign-based interventions.

Results: The reproduction number prior to the countermeasures ranged from 2.6 to 3.1 and then began to decrease following campaign-based interventions. After the first countermeasure, the reproduction number decreased, but the epidemic remained supercritical (i.e., R > 1). The value of R dropped well below one following the second countermeasure, which used web articles to widely disseminate information about the epidemic risk.

Conclusions: Although the effective reproduction number, R, changes because of both intrinsic and extrinsic factors, the timing of the examined countermeasures against hepatitis A in the MSM population was consistent with the abrupt declines observed in R. Even without vaccination, the epidemic was brought under control, and risky behaviors may have been changed by the increase in situation awareness reached through web articles.

Citing Articles

Transmission dynamics of the 2016-18 outbreak of hepatitis A among men who have sex with men in England and cost-effectiveness analysis of vaccination strategies to prevent future outbreaks.

Zhang X, Ong J, MacGregor L, Vilaplana T, Heathcock S, Mindlin M Lancet Reg Health Eur. 2022; 19:100426.

PMID: 36039276 PMC: 9417902. DOI: 10.1016/j.lanepe.2022.100426.

References

Comelli A, Izzo I, Casari S, Spinetti A, Bergamasco A, Castelli F . Hepatitis A outbreak in men who have sex with men (MSM) in Brescia (Northern Italy), July 2016-July 2017. Infez Med. 2018; 26(1):46-51. View

Freidl G, Sonder G, Bovee L, Friesema I, van Rijckevorsel G, Ruijs W . Hepatitis A outbreak among men who have sex with men (MSM) predominantly linked with the EuroPride, the Netherlands, July 2016 to February 2017. Euro Surveill. 2017; 22(8). PMC: 5356436. DOI: 10.2807/1560-7917.ES.2017.22.8.30468. View

Bonacic Marinovic A, Swaan C, van Steenbergen J, Kretzschmar M . Quantifying reporting timeliness to improve outbreak control. Emerg Infect Dis. 2015; 21(2):209-16. PMC: 4313625. DOI: 10.3201/eid2102.130504. View

Chen W, Chiang P, Liao Y, Huang L, Hsieh Y, Chiu C . Outbreak of hepatitis A virus infection in Taiwan, June 2015 to September 2017. Euro Surveill. 2019; 24(14). PMC: 6462791. DOI: 10.2807/1560-7917.ES.2019.24.14.1800133. View

Rodriguez-Tajes S, Perpinan E, Caballol B, Lens S, Marino Z, Costa J . Hepatitis A outbreak in Barcelona among men who have sex with men (MSM), January-June 2017: A hospital perspective. Liver Int. 2017; 38(4):588-593. DOI: 10.1111/liv.13606. View

Lin K, Sun H, Chen Y, Lo Y, Hsieh S, Sheng W . Effect of a Hepatitis A Vaccination Campaign During a Hepatitis A Outbreak in Taiwan, 2015-2017: A Modeling Study. Clin Infect Dis. 2019; 70(8):1742-1749. DOI: 10.1093/cid/ciz471. View

Gozlan Y, Bar-Or I, Rakovsky A, Savion M, Amitai Z, Sheffer R . Ongoing hepatitis A among men who have sex with men (MSM) linked to outbreaks in Europe in Tel Aviv area, Israel, December 2016 - June 2017. Euro Surveill. 2017; 22(29). PMC: 5532962. DOI: 10.2807/1560-7917.ES.2017.22.29.30575. View

Hu M, Schenzle D, Deinhardt F, Scheid R . Epidemiology of hepatitis A and B in the Shanghai area: prevalence of serum markers. Am J Epidemiol. 1984; 120(3):404-13. DOI: 10.1093/oxfordjournals.aje.a113905. View

Costantino A, Coppola N, Spada E, Bruni R, Taffon S, Equestre M . Hepatitis A virus strains circulating during 1997-2015 in Campania, a Southern Italy region with periodic outbreaks. J Med Virol. 2017; 89(11):1931-1936. DOI: 10.1002/jmv.24880. View

10.

Van Effelterre T, Zink T, Hoet B, Hausdorff W, Rosenthal P . A mathematical model of hepatitis a transmission in the United States indicates value of universal childhood immunization. Clin Infect Dis. 2006; 43(2):158-64. DOI: 10.1086/505115. View

11.

Fares A . Seasonality of hepatitis: a review update. J Family Med Prim Care. 2015; 4(1):96-100. PMC: 4367015. DOI: 10.4103/2249-4863.152263. View

12.

Takechi A, Hatakeyama S, Kashiyama T, Koibuchi T . [Outbreak of hepatitis A virus infection among men who have sex with men]. Kansenshogaku Zasshi. 2000; 74(9):716-9. DOI: 10.11150/kansenshogakuzasshi1970.74.716. View

13.

Ajelli M, Iannelli M, Manfredi P, Ciofi Degli Atti M . Basic mathematical models for the temporal dynamics of HAV in medium-endemicity Italian areas. Vaccine. 2008; 26(13):1697-707. DOI: 10.1016/j.vaccine.2007.12.058. View

14.

Van Effelterre T, Marano C, Jacobsen K . Modeling the hepatitis A epidemiological transition in Thailand. Vaccine. 2015; 34(4):555-562. DOI: 10.1016/j.vaccine.2015.11.052. View

15.

Chen N, Liu Z, Shie S, Chen T, Wu T . Clinical characteristics of acute hepatitis A outbreak in Taiwan, 2015-2016: observations from a tertiary medical center. BMC Infect Dis. 2017; 17(1):441. PMC: 5479032. DOI: 10.1186/s12879-017-2555-x. View

16.

Watanabe S, Morimoto N, Miura K, Takaoka Y, Nomoto H, Tsukui M . Full-genome characterization of the RIVM-HAV16-090-like hepatitis A virus strains recovered from Japanese men who have sex with men, with sporadic acute hepatitis A. Hepatol Res. 2019; 49(5):521-530. DOI: 10.1111/hepr.13313. View

17.

Bradley-Stewart A, Smith-Palmer A, Hawkins G, Gunson R . Hepatitis A-2017 an unusual year in Scotland. J Clin Virol. 2019; 115:1-4. DOI: 10.1016/j.jcv.2019.03.011. View

18.

Werber D, Michaelis K, Hausner M, Sissolak D, Wenzel J, Bitzegeio J . Ongoing outbreaks of hepatitis A among men who have sex with men (MSM), Berlin, November 2016 to January 2017 - linked to other German cities and European countries. Euro Surveill. 2017; 22(5). PMC: 5388120. DOI: 10.2807/1560-7917.ES.2017.22.5.30457. View

19.

Jacobsen K, Koopman J . The effects of socioeconomic development on worldwide hepatitis A virus seroprevalence patterns. Int J Epidemiol. 2005; 34(3):600-9. DOI: 10.1093/ije/dyi062. View

20.

Petersen J, Freedman J, Ford L, Gawthrop M, Simons H, Edelstein M . Changes to country-specific hepatitis A travel vaccination recommendation for UK travellers in 2017-responding to a vaccine shortage in the national context. Public Health. 2018; 168:150-156. DOI: 10.1016/j.puhe.2018.09.017. View