The Association Between Long-term Exposure to Ambient Fine Particulate Matter and Glaucoma: A Nation-wide Epidemiological Study Among Chinese Adults

Overview

Journal Int J Hyg Environ Health

Specialties Environmental Health
Public Health

Date 2021 Oct 11

PMID 34634756

Citations 11

Authors

Xueli Yang

Ze Yang

Yuanyuan Liu

Xi Chen

Baoqun Yao

Fengchao Liang

Anqi Shan

Fangchao Liu

Song Chen

Xiaochang Yan

Jianfeng Huang

Shaoye Bo

Yang Liu

Naijun Tang

Dongfeng Gu

Hua Yan

Affiliations

Soon will be listed here.

Abstract

Background: A growing body of evidence has confirmed the association between fine particulate matter (PM) and ocular diseases, but little is known on the effect of long-term PM exposure on glaucoma.

Methods: A national cross-sectional study of the Rural Epidemiology for Glaucoma was conducted in 10 provinces of China, and 33,701 adults aged 40 years or more were included. A satellite-based model at 1-km resolution level was used to estimate PM concentrations which were assigned to each participant according to geocoded home addresses. Logistic regression model was performed to investigate associations of long-term PM exposure with glaucoma and its subtypes.

Results: Estimated PM concentrations ranged from 28.0 to 96.4 μg/m. For each 10 μg/m increment in PM, the adjusted odds ratios (ORs) were 1.07 (95% CI: 1.00-1.15) and 1.14 (95% CI: 1.02-1.26) for glaucoma and primary angle-closure glaucoma (PACG), respectively. A positive but non-significant association (OR = 1.05, 95% CI: 0.92-1.18) was detected between long-term exposure to PM and odds of primary open-angle glaucoma. The middle aged residents and non-smokers were more sensitive to the adverse effects of PM.

Conclusions: Long-term PM exposure was associated with glaucoma and PACG in Chinese adults, which provided new insights on adverse ophthalmic effect of PM.

Citing Articles

Pathological Mechanisms of Particulate Matter-Mediated Ocular Disorders: A Review.

Han J, Amri C, Lee H, Hur J Int J Mol Sci. 2024; 25(22).

PMID: 39596177 PMC: 11594968. DOI: 10.3390/ijms252212107.

Impact of fine particulate matter (PM) on ocular health among people living in Chiang Mai, Thailand.

Kausar S, Tongchai P, Yadoung S, Sabir S, Pata S, Khamduang W Sci Rep. 2024; 14(1):26479.

PMID: 39489750 PMC: 11532337. DOI: 10.1038/s41598-024-77288-8.

Association of Ambient Air Pollution Exposure With Incident Glaucoma: 12-Year Evidence From the UK Biobank Cohort.

Sun Z, Stuart K, Luben R, Auld A, Strouthidis N, Khaw P Invest Ophthalmol Vis Sci. 2024; 65(12):22.

PMID: 39412818 PMC: 11488522. DOI: 10.1167/iovs.65.12.22.

Impact of Environmental Factors on Glaucoma Progression: A Systematic Review.

Almarzouki N Clin Ophthalmol. 2024; 18:2705-2720.

PMID: 39372224 PMC: 11451402. DOI: 10.2147/OPTH.S484855.

Association between ambient air pollution and age-related macular degeneration: a meta-analysis.

Wu J, Zhang Y, Xu X BMC Ophthalmol. 2024; 24(1):202.

PMID: 38684968 PMC: 11059589. DOI: 10.1186/s12886-024-03465-y.

References

Sun H, Luo C, Chiang Y, Yeh K, Li Y, Ho Y . Association Between PM Exposure Level and Primary Open-Angle Glaucoma in Taiwanese Adults: A Nested Case-Control Study. Int J Environ Res Public Health. 2021; 18(4). PMC: 7916685. DOI: 10.3390/ijerph18041714. View

Baudouin C, Kolko M, Melik-Parsadaniantz S, Messmer E . Inflammation in Glaucoma: From the back to the front of the eye, and beyond. Prog Retin Eye Res. 2020; 83:100916. DOI: 10.1016/j.preteyeres.2020.100916. View

Xiao Q, Chang H, Geng G, Liu Y . An Ensemble Machine-Learning Model To Predict Historical PM Concentrations in China from Satellite Data. Environ Sci Technol. 2018; 52(22):13260-13269. DOI: 10.1021/acs.est.8b02917. View

Takayanagi Y, Takai Y, Kaidzu S, Tanito M . Evaluation of Redox Profiles of the Serum and Aqueous Humor in Patients with Primary Open-Angle Glaucoma and Exfoliation Glaucoma. Antioxidants (Basel). 2020; 9(12). PMC: 7765903. DOI: 10.3390/antiox9121305. View

Chua J, Vania M, Cheung C, Ang M, Chee S, Yang H . Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes. Mol Vis. 2012; 18:431-8. PMC: 3283212. View

Huang K, Liang F, Yang X, Liu F, Li J, Xiao Q . Long term exposure to ambient fine particulate matter and incidence of stroke: prospective cohort study from the China-PAR project. BMJ. 2020; 367:l6720. PMC: 7190010. DOI: 10.1136/bmj.l6720. View

Takai Y, Tanito M, Ohira A . Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract. Invest Ophthalmol Vis Sci. 2011; 53(1):241-7. DOI: 10.1167/iovs.11-8434. View

Cohen A, Brauer M, Burnett R, Anderson H, Frostad J, Estep K . Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015. Lancet. 2017; 389(10082):1907-1918. PMC: 5439030. DOI: 10.1016/S0140-6736(17)30505-6. View

Mimura T, Ichinose T, Yamagami S, Fujishima H, Kamei Y, Goto M . Airborne particulate matter (PM2.5) and the prevalence of allergic conjunctivitis in Japan. Sci Total Environ. 2014; 487:493-9. DOI: 10.1016/j.scitotenv.2014.04.057. View

10.

Jung S, Mehta J, Tong L . Effects of environment pollution on the ocular surface. Ocul Surf. 2018; 16(2):198-205. DOI: 10.1016/j.jtos.2018.03.001. View

11.

Torricelli A, Novaes P, Matsuda M, Alves M, Monteiro M . Ocular surface adverse effects of ambient levels of air pollution. Arq Bras Oftalmol. 2011; 74(5):377-81. DOI: 10.1590/s0004-27492011000500016. View

12.

Quigley H . Glaucoma. Lancet. 2011; 377(9774):1367-77. DOI: 10.1016/S0140-6736(10)61423-7. View

13.

Nongpiur M, He M, Amerasinghe N, Friedman D, Tay W, Baskaran M . Lens vault, thickness, and position in Chinese subjects with angle closure. Ophthalmology. 2010; 118(3):474-9. DOI: 10.1016/j.ophtha.2010.07.025. View

14.

Xia B, Zhou Y, Zhu Q, Zhao Y, Wang Y, Ge W . Personal exposure to PM constituents associated with gestational blood pressure and endothelial dysfunction. Environ Pollut. 2019; 250:346-356. DOI: 10.1016/j.envpol.2019.04.024. View

15.

Liu S, Jorgensen J, Ljungman P, Pershagen G, Bellander T, Leander K . Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project. Eur Respir J. 2021; 57(6). DOI: 10.1183/13993003.03099-2020. View

16.

Turner M, Andersen Z, Baccarelli A, Diver W, Gapstur S, Pope 3rd C . Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations. CA Cancer J Clin. 2020; . PMC: 7904962. DOI: 10.3322/caac.21632. View

17.

Calderon-Garciduenas L, Franco-Lira M, DAngiulli A, Rodriguez-Diaz J, Blaurock-Busch E, Busch Y . Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and.... Environ Res. 2015; 140:579-92. DOI: 10.1016/j.envres.2015.05.012. View

18.

Jonas J, Aung T, Bourne R, Bron A, Ritch R, Panda-Jonas S . Glaucoma. Lancet. 2017; 390(10108):2183-2193. DOI: 10.1016/S0140-6736(17)31469-1. View

19.

. Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2020; 9(2):e130-e143. PMC: 7820390. DOI: 10.1016/S2214-109X(20)30425-3. View

20.

Shan A, Chen X, Yang X, Yao B, Liang F, Yang Z . Association between long-term exposure to fine particulate matter and diabetic retinopathy among diabetic patients: A national cross-sectional study in China. Environ Int. 2021; 154:106568. DOI: 10.1016/j.envint.2021.106568. View