Evolution of Baseline Characteristics and Severe Outcomes in COVID-19 Inpatients During the First and Second Waves in Northeastern France

Overview

Journal Infect Dis Now

Specialty Infectious Diseases

Date 2021 Oct 11

PMID 34634485

Citations 7

Authors

M Martinot

M Eyriey

S Gravier

D Kayser

C Ion

M Mohseni-Zadeh

J C Ongagna

A Schieber

C Kempf

Affiliations

Soon will be listed here.

Abstract

Objectives: Two COVID-19 epidemic waves occurred in France in 2020. This single-center retrospective study compared patients' characteristics and outcomes.

Patients And Methods: We included all patients with confirmed COVID-19 admitted to Colmar Hospital in March (n=600) and October/November (n=205) 2020.

Results: Median ages, sex ratio, body mass index, and number of comorbidities were similar in wave 1 and 2 patients. Significant differences were found for temperature (38°C vs. 37.2), need for oxygen (38.6% vs. 26.8%), high-flow cannula (0% vs. 8.3%), and steroid use (6.3% vs. 54.1%). Intensive care unit (ICU) hospitalizations (25.5% vs. 15.1%, OR: 0.44, 95% CI [0.28; 0.68], P=0.002) and deaths (19.2% vs. 12.7%, OR: 0.61, 95% CI [0.37; 0.98], P=0.04) decreased during the second wave. Except for cardiovascular events (5.5% vs. 10.2%), no change was observed in extrapulmonary events.

Conclusions: Deaths and ICU hospitalizations were significantly reduced during the second epidemic wave.

Citing Articles

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Characteristic and outcome changes in inpatients with COVID-19 during the four pre - Omicron waves.

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Lehmann M, Peeters S, Streuter M, Nawrocki M, Kosters K, Kroger K Dtsch Med Wochenschr. 2022; 148(4):e14-e20.

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