Large-scale Whole-exome Sequencing Association Study Identifies FOXH1 Gene and Sphingolipid Metabolism Pathway Influencing Major Depressive Disorder

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2021 Oct 11

PMID 34633764

Citations 5

Authors

Wei Zhou

Luan Chen

Bixuan Jiang

Yidan Sun

Mo Li

Hao Wu

Na Zhang

Xiaofang Sun

Shengying Qin

Affiliations

Soon will be listed here.

Abstract

In the present study, we performed an exome-wide investigation of the burden of rare disease-causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene-based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant association with MDD. In addition, sphingolipid metabolism pathway was found to be less enriched with rare disease-causing variants in the MDD group, suggesting that this gene set may be involved in the pathophysiology of MDD.

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