Colonic Expression of , the SARS-CoV-2 Entry Receptor, is Suppressed by Commensal Human Microbiota

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2021 Oct 11

PMID 34632957

Citations 13

Authors

Adam Edwinson

Lu Yang

Jun Chen

Madhusudan Grover

Affiliations

Soon will be listed here.

Abstract

Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Angiotensin-converting enzyme 2 () is expressed in the gastrointestinal (GI) tract and a receptor for SARS-CoV-2, making the GI tract a potential infection site. This study investigated the effects of commensal intestinal microbiota on colonic expression using a humanized mouse model. We found that colonic expression decreased significantly upon microbial colonization. Humanization with healthy volunteer or dysbiotic microbiota from irritable bowel syndrome (IBS) patients resulted in similar expression. Despite the differences in microbiota, no associations between α-diversity, β-diversity or individual taxa, and were noted post-humanization. These results highlight that commensal microbiota play a key role in regulating intestinal expression and the need to further examine the underlying mechanisms of this regulation.

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