Diagnostic Challenges in Systemic Amyloidosis: a Case Report with Clinical and Laboratorial Pitfalls

Overview

Journal Autops Case Rep

Date 2021 Oct 11

PMID 34631606

Authors

Angelina Maria Martins Lino

Jussara Bianchi Castelli

Roberta Shcolnik Szor

Fabio Fernandes

Vera Demarchi Aiello

Affiliations

Soon will be listed here.

Abstract

Currently, there is growing evidence in the literature warning of misdiagnosis involving amyloidosis and chronic inflammatory demyelinating polyneuropathy (CIDP). Although inducing clinical manifestations outside the peripheral nervous system, light chain and transthyretin amyloidosis may initially present with peripheral neuropathy, which can be indistinguishable from CIDP, leading to a delay in the correct diagnosis. Besides, the precise identification of the amyloid subtype is often challenging. This case report exemplifies clinical and laboratory pitfalls in diagnosing amyloidosis and subtyping amyloid, exposing the patient to potentially harmful procedures.

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