The Aged Intestine: Performance and Rejuvenation

Overview

Journal Aging Dis

Specialty Geriatrics

Date 2021 Oct 11

PMID 34631215

Citations 8

Authors

Qiwen Wang

Yadong Qi

Weiyi Shen

Jilei Xu

Lan Wang

Shujie Chen

Tongyao Hou

Jianmin Si

Affiliations

Soon will be listed here.

Abstract

Owing to the growing elderly population, age-related problems are gaining increasing attention from the scientific community. With senescence, the intestine undergoes a spectrum of changes and infirmities that are likely the causes of overall aging. Therefore, identification of the aged intestine and the search for novel strategies to rescue it, are required. Although progress has been made in research on some components of the aged intestine, such as intestinal stem cells, the comprehensive understanding of intestinal aging is still limited, and this restricts the in-depth search for efficient strategies. In this concise review, we discuss several aspects of intestinal aging. More emphasis is placed on the appraisal of current and potential strategies to alleviate intestinal aging, as well as future targets to rejuvenate the aged intestine.

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