The Prognostic Value of Serum Uric Acid in Hospitalized Patients with Acute Cerebral Infarction

Background: Previous studies reported that the level of serum uric acid (SUA) was an important risk factor for acute cerebral infarction (ACI). However, the prognostic value of SUA levels in hospitalized patients with ACI has not been fully elucidated. The aim of this study was to investigate whether the SUA level on admission was associated with subsequent mortality in hospitalized patients with ACI.

Methods: The clinical data of ACI patients obtained from December 2017 to December 2019 were retrospectively reviewed. and Kaplan-Meier methods were used to compare the clinical differences and overall survival between patients with or without hyperuricemia, respectively. Univariate and multivariate analyses were used to identify independent prognoses.

Results: In the total population, the in-hospital mortality of the hyperuricemia group was significantly higher than that of the normal uric acid group ( = 0.006). In the abnormal renal function group, the in-hospital mortality among the hyperuricemia group was significantly higher than the normal uric acid group ( = 0.002). However, there was no statistical difference of in-hospital mortality between the two groups in the normal renal function group ( = 0.321). Univariate and multivariate analyses showed that a previous history of diabetes ( = 0.018), hyperuricemia ( = 0.001), and National Institutes of Health Stroke Scale (NIHSS) score on admission ( ≤ 0.001) were independent factors for all samples. The hyperuricemia ( = 0.003) on admission were independent factors for patients with abnormal renal function.

Conclusions: In ACI patients with abnormal renal function, hyperuricemia may be associated with higher in-hospital mortality than patients with normal uric acid, and hyperuricemia may be an independent associated factor for in-hospital death in the subgroup patients.