Upper-Critical-Solution-Temperature Polymer Modified Gold Nanorods for Laser Controlled Drug Release and Enhanced Anti-Tumour Therapy

Overview

Journal Front Pharmacol

Date 2021 Oct 11

PMID 34630113

Citations 2

Authors

Que Lin

Mao Jia

Yi Fu

Bei Li

Zhigang Dong

Xiaoya Niu

Zhen You

Affiliations

Soon will be listed here.

Abstract

Photothermal therapy (PTT) has become effective method for the treatment of malignant cancer. The development of PTT system with high anti-tumour effect is still the feasible research direction. Here, a new type of gold nanorods (AuNRs)-doxorubicin (DOX)/mPEG-peptide/P(AAm-co-AN) (APP-DOX) nano drug delivery system was proposed. Among them, AuNRs was used as high-efficiency photothermal agent. APP-DOX had a suitable size and can be targeted to accumulate in tumour tissues through circulation in the body. The abundant matrix metalloproteinase 2 (MMP-2) in the tumour environment intercepted and cut off the short peptide chain structure grafted on APP-DOX. At the same time, the removal of the PEG segment leaded to an increase in the hydrophobic properties of the system. Nanoparticles aggregated into large particles, causing them to stay and aggregate further at the tumour site. When irradiated by 808 nm near-infrared laser, APP-DOX achieved a gradual heating process. High temperature can effectively ablate tumours and enable UCST polymer to achieve phase transition, resulting in more anti-cancer drugs loaded in the polymer layer DOX was released, effectively killing cancer cells. Animal experiments had verified the possibility of the nano drug-carrying system and good tumour treatment effect. What's more worth mentioning is that compared with free DOX, the nano drug delivery system had lower biological toxicity and not cause obvious harmful effects on normal organs and tissues.

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References

Chuang C, Chen Y, Wang Y, Huang Y, Lin S, Huang R . Stem Cell-Based Delivery of Gold/Chlorin e6 Nanocomplexes for Combined Photothermal and Photodynamic Therapy. ACS Appl Mater Interfaces. 2020; 12(27):30021-30030. DOI: 10.1021/acsami.0c03446. View

Yadav R, Kumar S, Narang P, Venkatesu P . How does the addition of shape distinct gold nanoparticles influence on the conformational transition of poly(N-isopropylacrylamide)?. J Colloid Interface Sci. 2020; 582(Pt B):478-487. DOI: 10.1016/j.jcis.2020.08.074. View

Zhang C, Cheng X, Chen M, Sheng J, Ren J, Jiang Z . Fluorescence guided photothermal/photodynamic ablation of tumours using pH-responsive chlorin e6-conjugated gold nanorods. Colloids Surf B Biointerfaces. 2017; 160:345-354. DOI: 10.1016/j.colsurfb.2017.09.045. View

Asadujjaman A, Kent B, Bertin A . Phase transition and aggregation behaviour of an UCST-type copolymer poly(acrylamide-co-acrylonitrile) in water: effect of acrylonitrile content, concentration in solution, copolymer chain length and presence of electrolyte. Soft Matter. 2016; 13(3):658-669. DOI: 10.1039/c6sm02262f. View

Tian J, Huang B, Li H, Cao H, Zhang W . NIR-Activated Polymeric Nanoplatform with Upper Critical Solution Temperature for Image-Guided Synergistic Photothermal Therapy and Chemotherapy. Biomacromolecules. 2019; 20(6):2338-2349. DOI: 10.1021/acs.biomac.9b00321. View

Wang Y, Wang F, Liu Y, Xu S, Shen Y, Feng N . Glutathione detonated and pH responsive nano-clusters of Au nanorods with a high dose of DOX for treatment of multidrug resistant cancer. Acta Biomater. 2018; 75:334-345. DOI: 10.1016/j.actbio.2018.06.012. View

S R, M P . Multi-functional FITC-silica@gold nanoparticles conjugated with guar gum succinate, folic acid and doxorubicin for CT/fluorescence dual imaging and combined chemo/PTT of cancer. Colloids Surf B Biointerfaces. 2019; 186:110701. DOI: 10.1016/j.colsurfb.2019.110701. View

Gao L, Zhang L, Zhu X, Chen J, Zhao M, Li S . Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy. J Mater Chem B. 2020; 8(22):4841-4845. DOI: 10.1039/d0tb00097c. View

Kingsley J, Dou H, Morehead J, Rabinow B, Gendelman H, Destache C . Nanotechnology: a focus on nanoparticles as a drug delivery system. J Neuroimmune Pharmacol. 2007; 1(3):340-50. DOI: 10.1007/s11481-006-9032-4. View

10.

Hou Y, Yang X, Liu R, Zhao D, Guo C, Zhu A . Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles. Int J Nanomedicine. 2020; 15:6827-6838. PMC: 7501968. DOI: 10.2147/IJN.S269321. View

11.

Wang F, Huang Q, Wang Y, Zhang W, Lin R, Yu Y . Rational design of multimodal therapeutic nanosystems for effective inhibition of tumor growth and metastasis. Acta Biomater. 2018; 77:240-254. DOI: 10.1016/j.actbio.2018.07.025. View

12.

Liu K, Cao H, Yuan W, Bao Y, Shan G, Wu Z . Stereocomplexed and homocrystalline thermo-responsive physical hydrogels with a tunable network structure and thermo-responsiveness. J Mater Chem B. 2020; 8(35):7947-7955. DOI: 10.1039/d0tb01484b. View

13.

Cooperstein M, Canavan H . Assessment of cytotoxicity of (N-isopropyl acrylamide) and poly(N-isopropyl acrylamide)-coated surfaces. Biointerphases. 2014; 8(1):19. PMC: 3979476. DOI: 10.1186/1559-4106-8-19. View

14.

Deng X, Liang H, Yang W, Shao Z . Polarization and function of tumor-associated macrophages mediate graphene oxide-induced photothermal cancer therapy. J Photochem Photobiol B. 2020; 208:111913. DOI: 10.1016/j.jphotobiol.2020.111913. View

15.

Thoenes W, Storkel S, Rumpelt H . Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract. 1986; 181(2):125-43. DOI: 10.1016/S0344-0338(86)80001-2. View

16.

Zheng L, Zhang B, Chu H, Cheng P, Li H, Huang K . Assembly and in vitro assessment of a powerful combination: aptamer-modified exosomes combined with gold nanorods for effective photothermal therapy. Nanotechnology. 2020; 31(48):485101. DOI: 10.1088/1361-6528/abb0b8. View

17.

Alvarez-Lorenzo C, Grinberg V, Burova T, Concheiro A . Stimuli-sensitive cross-linked hydrogels as drug delivery systems: Impact of the drug on the responsiveness. Int J Pharm. 2020; 579:119157. DOI: 10.1016/j.ijpharm.2020.119157. View

18.

Metawea O, Abdelmoneem M, Haiba N, Khalil H, Teleb M, Elzoghby A . A novel 'smart' PNIPAM-based copolymer for breast cancer targeted therapy: Synthesis, and characterization of dual pH/temperature-responsive lactoferrin-targeted PNIPAM-co-AA. Colloids Surf B Biointerfaces. 2021; 202:111694. DOI: 10.1016/j.colsurfb.2021.111694. View

19.

Choi J, Lee S, Park J, Kim S . Gold nanorod-photosensitizer conjugates with glutathione-sensitive linkages for synergistic cancer photodynamic/photothermal therapy. Biotechnol Bioeng. 2017; 115(5):1340-1354. DOI: 10.1002/bit.26536. View

20.

Li X, Lovell J, Yoon J, Chen X . Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol. 2020; 17(11):657-674. DOI: 10.1038/s41571-020-0410-2. View