CENPA Promotes Clear Cell Renal Cell Carcinoma Progression and Metastasis Via Wnt/β-catenin Signaling Pathway

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2021 Oct 10

PMID 34627268

Citations 39

Authors

Qi Wang

Jiaju Xu

Zhiyong Xiong

Tianbo Xu

Jingchong Liu

Yuenan Liu

Jiaping Chen

Jian Shi

Yi Shou

Changjie Yue

Di Liu

Huageng Liang

Hongmei Yang

Xiong Yang

Xiaoping Zhang

Affiliations

Soon will be listed here.

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The CENP family is overexpressed in many types of cancers, but its functions in ccRCC have not been fully clarified. In this paper, we found that several CENP family members were highly expressed in ccRCC tissues. Also, CENPA expression level was related to clinicopathological grade and prognosis by weighted gene co-expression network analysis (WGCNA). CENPA served as a representative CENP family member as a ccRCC biomarker. Further in vitro experiments verified that overexpression of CENPA promoted ccRCC proliferation and metastasis by accelerating the cell cycle and activating the Wnt/β-catenin signaling pathway. The elevated β-catenin led by CENPA overexpression translocated to nucleus for downstream effect. Functional recovery experiment confirmed that Wnt/β-catenin pathway was essential for ccRCC progression and metastasis. Developing selective drugs targeting CENPA may be a promising direction for cancer treatment.

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