Alcohol Use Disorder and Recent Alcohol Use and HIV Viral Non-Suppression Among People Engaged in HIV Care in an Urban Clinic, 2014-2018

Overview

Journal AIDS Behav

Specialty Infectious Diseases

Date 2021 Oct 9

PMID 34626264

Citations 4

Authors

Catherine R Lesko

Heidi E Hutton

Jessie K Edwards

Mary E McCaul

Anthony T Fojo

Jeanne C Keruly

Richard D Moore

Geetanjali Chander

Affiliations

Soon will be listed here.

Abstract

We estimated joint associations between having history of alcohol use disorder (AUD) (based on prior ICD-9/ICD-10 codes) and recent self-reported alcohol use and viral non-suppression (≥ 1 viral load measurement > 20 copies/mL in the same calendar year as alcohol consumption was reported) among patients on ART enrolled in routine care, 2014-2018, in an urban specialty clinic. Among 1690 patients, 26% had an AUD, 21% reported high-risk alcohol use, and 39% had viral non-suppression. Relative to person-years in which people without AUD reported not drinking, prevalence of viral non-suppression was higher in person-years when people with AUD reported drinking at any level; prevalence of viral non-suppression was not significantly higher in person-years when people with AUD reported not drinking or person-years when people without AUD reported drinking at any level. No level of alcohol use may be "safe" for people with a prior AUD with regard to maintaining viral suppression.

Citing Articles

Association of Alcohol Use with COVID-19 Infection and Hospitalization Among People Living with HIV in the United States, 2020.

Xia C, Chander G, Hutton H, McCaul M, Delaney J, Mayer K AIDS Behav. 2024; 28(5):1795-1807.

PMID: 38421512 PMC: 11238908. DOI: 10.1007/s10461-024-04301-6.

Implementing a peer-supported, integrated strategy for substance use disorder care in an outpatient infectious disease clinic is associated with improved patient outcomes.

Falade-Nwulia O, Agee T, Kelly S, Park J, Schwartz S, Hsu J Int J Drug Policy. 2023; 121:104191.

PMID: 37740989 PMC: 10844957. DOI: 10.1016/j.drugpo.2023.104191.

Joint effects of substance use disorders and recent substance use on HIV viral non-suppression among people engaged in HIV care in an urban clinic, 2014-2019.

Lesko C, Falade-Nwulia O, Pytell J, Hutton H, Fojo A, Keruly J Addiction. 2023; 118(11):2193-2202.

PMID: 37491566 PMC: 10592031. DOI: 10.1111/add.16301.

Alcohol use and the longitudinal HIV care continuum for people with HIV who enrolled in care between 2011 and 2019.

Lesko C, Gnang J, Fojo A, Hutton H, McCaul M, Delaney J Ann Epidemiol. 2023; 85:6-12.

PMID: 37442307 PMC: 10538410. DOI: 10.1016/j.annepidem.2023.07.002.

References

Wu E, Metzger D, Lynch K, Douglas S . Association between alcohol use and HIV viral load. J Acquir Immune Defic Syndr. 2011; 56(5):e129-30. PMC: 3082398. DOI: 10.1097/QAI.0b013e31820dc1c8. View

Satre D, Sarovar V, Leyden W, Hare C, Catz S, Bryant K . Changes in Days of Unhealthy Alcohol Use and Antiretroviral Therapy Adherence, HIV RNA Levels, and Condomless Sex: A Secondary Analysis of Clinical Trial Data. AIDS Behav. 2019; 24(6):1784-1792. PMC: 7406176. DOI: 10.1007/s10461-019-02742-y. View

Sato T, Matsuyama Y . Marginal structural models as a tool for standardization. Epidemiology. 2003; 14(6):680-6. DOI: 10.1097/01.EDE.0000081989.82616.7d. View

Chander G, Monroe A, Crane H, Hutton H, Saag M, Cropsey K . HIV primary care providers--Screening, knowledge, attitudes and behaviors related to alcohol interventions. Drug Alcohol Depend. 2016; 161:59-66. PMC: 4841449. DOI: 10.1016/j.drugalcdep.2016.01.015. View

Edwards J, Cole S, Fox M . Flexibly Accounting for Exposure Misclassification With External Validation Data. Am J Epidemiol. 2020; 189(8):850-860. PMC: 7608057. DOI: 10.1093/aje/kwaa011. View

Cohen M, Chen Y, McCauley M, Gamble T, Hosseinipour M, Kumarasamy N . Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011; 365(6):493-505. PMC: 3200068. DOI: 10.1056/NEJMoa1105243. View

Higgins-Biddle J, Babor T . A review of the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-C, and USAUDIT for screening in the United States: Past issues and future directions. Am J Drug Alcohol Abuse. 2018; 44(6):578-586. PMC: 6217805. DOI: 10.1080/00952990.2018.1456545. View

Williams E, McGinnis K, Rubinsky A, Matson T, Bobb J, Lapham G . Alcohol Use and Antiretroviral Adherence Among Patients Living with HIV: Is Change in Alcohol Use Associated with Change in Adherence?. AIDS Behav. 2020; 25(1):203-214. PMC: 7775874. DOI: 10.1007/s10461-020-02950-x. View

Cook R, Zhou Z, Kelso-Chichetto N, Janelle J, Morano J, Somboonwit C . Alcohol consumption patterns and HIV viral suppression among persons receiving HIV care in Florida: an observational study. Addict Sci Clin Pract. 2017; 12(1):22. PMC: 5615807. DOI: 10.1186/s13722-017-0090-0. View

10.

Harris A, Kivlahan D, Bowe T, Humphreys K . Pharmacotherapy of alcohol use disorders in the Veterans Health Administration. Psychiatr Serv. 2010; 61(4):392-8. DOI: 10.1176/ps.2010.61.4.392. View

11.

Vagenas P, Azar M, Copenhaver M, Springer S, Molina P, Altice F . The Impact of Alcohol Use and Related Disorders on the HIV Continuum of Care: a Systematic Review : Alcohol and the HIV Continuum of Care. Curr HIV/AIDS Rep. 2015; 12(4):421-36. PMC: 4643391. DOI: 10.1007/s11904-015-0285-5. View

12.

Yehia B, Fleishman J, Metlay J, Moore R, Gebo K . Sustained viral suppression in HIV-infected patients receiving antiretroviral therapy. JAMA. 2012; 308(4):339-42. PMC: 3541503. DOI: 10.1001/jama.2012.5927. View

13.

Moore R . Understanding the clinical and economic outcomes of HIV therapy: the Johns Hopkins HIV clinical practice cohort. J Acquir Immune Defic Syndr Hum Retrovirol. 1998; 17 Suppl 1:S38-41. DOI: 10.1097/00042560-199801001-00011. View

14.

Lesko C, Chander G, Moore R, Lau B . Variation in estimated viral suppression associated with the definition of viral suppression used. AIDS. 2020; 34(10):1519-1526. PMC: 8327702. DOI: 10.1097/QAD.0000000000002579. View

15.

Lundgren J, Babiker A, Gordin F, Emery S, Grund B, Sharma S . Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. N Engl J Med. 2015; 373(9):795-807. PMC: 4569751. DOI: 10.1056/NEJMoa1506816. View

16.

Williams E, McGinnis K, Bobb J, Rubinsky A, Lapham G, Skanderson M . Changes in alcohol use associated with changes in HIV disease severity over time: A national longitudinal study in the Veterans Aging Cohort. Drug Alcohol Depend. 2018; 189:21-29. PMC: 6344121. DOI: 10.1016/j.drugalcdep.2018.04.022. View

17.

Lesko C, Keil A, Moore R, Chander G, Fojo A, Lau B . Measurement of Current Substance Use in a Cohort of HIV-Infected Persons in Continuity HIV Care, 2007-2015. Am J Epidemiol. 2018; 187(9):1970-1979. PMC: 6118067. DOI: 10.1093/aje/kwy092. View

18.

Valdiserri R, Forsyth A, Yakovchenko V, Koh H . Measuring what matters: development of standard HIV core indicators across the U.S. Department of Health and Human Services. Public Health Rep. 2013; 128(5):354-9. PMC: 3743282. DOI: 10.1177/003335491312800504. View

19.

Crane H, McCaul M, Chander G, Hutton H, Nance R, Delaney J . Prevalence and Factors Associated with Hazardous Alcohol Use Among Persons Living with HIV Across the US in the Current Era of Antiretroviral Treatment. AIDS Behav. 2017; 21(7):1914-1925. PMC: 5628735. DOI: 10.1007/s10461-017-1740-7. View

20.

Williams E, Hahn J, Saitz R, Bryant K, Lira M, Samet J . Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions. Alcohol Clin Exp Res. 2016; 40(10):2056-2072. PMC: 5119641. DOI: 10.1111/acer.13204. View