Identification of Strains for Gut Microbiome-based Intervention in Alzheimer's-type Dementia

Overview

Journal Cell Rep Med

Publisher Cell Press

Specialties Biology
General Medicine

Date 2021 Oct 8

PMID 34622235

Citations 43

Authors

Atsushi Ueda

Shoji Shinkai

Hirotsugu Shiroma

Yu Taniguchi

Sayaka Tsuchida

Takahiro Kariya

Tomohiro Kawahara

Yodai Kobayashi

Noriyuki Kohda

Kazunari Ushida

Akihiko Kitamura

Takuji Yamada

Affiliations

Soon will be listed here.

Abstract

Evidence linking the gut-brain axis to Alzheimer's disease (AD) is accumulating, but the characteristics of causally important microbes are poorly understood. We perform a fecal microbiome analysis in healthy subjects and those with mild cognitive impairment (MCI) and AD. We find that () correlates with cognitive scores and decreases in the MCI group compared with the healthy group. Two isolated strains from the healthy group, live Fp360 and pasteurized Fp14, improve cognitive impairment in an AD mouse model. Whole-genome comparison of isolated strains reveals specific orthologs that are found only in the effective strains and are more abundant in the healthy group compared with the MCI group. Metabolome and RNA sequencing analyses of mouse brains provides mechanistic insights into the relationship between the efficacy of pasteurized Fp14, oxidative stress, and mitochondrial function. We conclude that strains with these specific orthologs are candidates for gut microbiome-based intervention in Alzheimer's-type dementia.

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