Possible Potentials of Curcumin for Pregnancies Complicated by Intra-uterine Growth Restriction: Role of Inflammation, Angiogenesis, and Oxidative Stress

Overview

Journal Heliyon

Specialty Social Sciences

Date 2021 Oct 8

PMID 34622047

Citations 1

Authors

Mahsa Naemi

Zahra Farahani

Amir Hossein Norooznezhad

Reza Khodarahmi

Sedigheh Hantoushzadeh

Roghaye Ahangari

Mamak Shariat

Affiliations

Soon will be listed here.

Abstract

Objectives: So far, various etiologies have been stated for Intra-uterine growth restriction (IUGR) with a wide variety of pathways involved in their pathogenesis. Among these pathways, impaired angiogenesis, inflammation, and oxidative stress are among the most important ones. Curcumin has raised notable attention due to its anti-inflammatory and antioxidant activity in different studies and clinical trials. The present study aimed to investigate the possible potentials of Curcumin for pregnancies complicated by IUGR through different physiological mechanisms.

Methods: A narrative review study was conducted (Iran; 2020). The implemented Mesh-based keywords were "Curcumin" OR "Turmeric" AND "Therapeutic effect" AND "Side effect" OR "Adverse effect" OR "Teratogenic effect" OR "Teratogenicity" AND "Pregnancy" AND "Intra-uterine growth restriction" OR "Intra-uterine growth retardation" AND "Inflammation" AND "Oxidative stress" AND "Angiogenesis". Cochrane Library, PubMed, Up to date, Scopus, and Google Scholar databases were used as academic search engines.

Results: Reviewing the included studies showed the dual effects of curcumin on angiogenesis depend on the type of angiogenesis: physiological or pathological. Interestingly, the present study evaluated the current knowledge on the effects of curcumin on IUGR demonstrating acceptable potentials. Also, we tried to gather studies that had evaluated the safety of curcumin during pregnancy.

Conclusion: Gathering all the data, it seems curcumin could be an acceptable candidate for future animal and human studies on IUGR.

Citing Articles

Oxidative Stress Induced by Antivirals: Implications for Adverse Outcomes During Pregnancy and in Newborns.

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PMID: 39765846 PMC: 11727424. DOI: 10.3390/antiox13121518.

Curcumin and Intestinal Oxidative Stress of Pigs With Intrauterine Growth Retardation: A Review.

Tang X, Xiong K, Wassie T, Wu X Front Nutr. 2022; 9:847673.

PMID: 35571913 PMC: 9101057. DOI: 10.3389/fnut.2022.847673.

References

Feghali M, Venkataramanan R, Caritis S . Pharmacokinetics of drugs in pregnancy. Semin Perinatol. 2015; 39(7):512-9. PMC: 4809631. DOI: 10.1053/j.semperi.2015.08.003. View

Wixey J, Chand K, Colditz P, Bjorkman S . Review: Neuroinflammation in intrauterine growth restriction. Placenta. 2016; 54:117-124. DOI: 10.1016/j.placenta.2016.11.012. View

Pinlaor S, Yongvanit P, Prakobwong S, Kaewsamut B, Khoontawad J, Pinlaor P . Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini. Mol Nutr Food Res. 2009; 53(10):1316-28. DOI: 10.1002/mnfr.200800567. View

Saker M, Soulimane Mokhtari N, Merzouk S, Merzouk H, Belarbi B, Narce M . Oxidant and antioxidant status in mothers and their newborns according to birthweight. Eur J Obstet Gynecol Reprod Biol. 2008; 141(2):95-9. DOI: 10.1016/j.ejogrb.2008.07.013. View

Bonello S, Zahringer C, BelAiba R, Djordjevic T, Hess J, Michiels C . Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler Thromb Vasc Biol. 2007; 27(4):755-61. DOI: 10.1161/01.ATV.0000258979.92828.bc. View

Zygmunt M, Herr F, Munstedt K, Lang U, Liang O . Angiogenesis and vasculogenesis in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2003; 110 Suppl 1:S10-8. DOI: 10.1016/s0301-2115(03)00168-4. View

Hracsko Z, Orvos H, Novak Z, Pal A, Varga I . Evaluation of oxidative stress markers in neonates with intra-uterine growth retardation. Redox Rep. 2008; 13(1):11-6. DOI: 10.1179/135100008X259097. View

Alahakoon T, Medbury H, Williams H, Fewings N, Wang X, Lee V . Distribution of monocyte subsets and polarization in preeclampsia and intrauterine fetal growth restriction. J Obstet Gynaecol Res. 2018; 44(12):2135-2148. DOI: 10.1111/jog.13770. View

Norooznezhad A, Norooznezhad F . Cannabinoids: Possible agents for treatment of psoriasis via suppression of angiogenesis and inflammation. Med Hypotheses. 2017; 99:15-18. DOI: 10.1016/j.mehy.2016.12.003. View

10.

Raghupathy R, Al-Azemi M, Azizieh F . Intrauterine growth restriction: cytokine profiles of trophoblast antigen-stimulated maternal lymphocytes. Clin Dev Immunol. 2011; 2012:734865. PMC: 3205724. DOI: 10.1155/2012/734865. View

11.

He J, Niu Y, Wang F, Wang C, Cui T, Bai K . Dietary curcumin supplementation attenuates inflammation, hepatic injury and oxidative damage in a rat model of intra-uterine growth retardation. Br J Nutr. 2018; 120(5):537-548. DOI: 10.1017/S0007114518001630. View

12.

Panahi Y, Hosseini M, Khalili N, Naimi E, Simental-Mendia L, Majeed M . Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother. 2016; 82:578-82. DOI: 10.1016/j.biopha.2016.05.037. View

13.

Niu Y, He J, Ahmad H, Shen M, Zhao Y, Gan Z . Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation. Nutrients. 2019; 11(12). PMC: 6950043. DOI: 10.3390/nu11122978. View

14.

Barut F, Barut A, Dogan Gun B, Onak Kandemir N, Harma M, Harma M . Intrauterine growth restriction and placental angiogenesis. Diagn Pathol. 2010; 5:24. PMC: 2865442. DOI: 10.1186/1746-1596-5-24. View

15.

Giordano A, Tommonaro G . Curcumin and Cancer. Nutrients. 2019; 11(10). PMC: 6835707. DOI: 10.3390/nu11102376. View

16.

Mostafaei S, Norooznezhad F, Mohammadi S, Norooznezhad A . Effectiveness of platelet-rich plasma therapy in wound healing of pilonidal sinus surgery: A comprehensive systematic review and meta-analysis. Wound Repair Regen. 2017; 25(6):1002-1007. DOI: 10.1111/wrr.12597. View

17.

Abrahams S, Haylett W, Johnson G, Carr J, Bardien S . Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience. 2019; 406:1-21. DOI: 10.1016/j.neuroscience.2019.02.020. View

18.

Casanello P, Sobrevia L . Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y+/hCAT-1 and y+/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells. Circ Res. 2002; 91(2):127-34. DOI: 10.1161/01.res.0000027813.55750.e7. View

19.

Hung T, Chen S, Lo L, Li M, Yeh Y, Hsieh T . Myeloperoxidase in the plasma and placenta of normal pregnant women and women with pregnancies complicated by preeclampsia and intrauterine growth restriction. Placenta. 2012; 33(4):294-303. DOI: 10.1016/j.placenta.2012.01.004. View

20.

Holcberg G, Huleihel M, Sapir O, Katz M, Tsadkin M, Furman B . Increased production of tumor necrosis factor-alpha TNF-alpha by IUGR human placentae. Eur J Obstet Gynecol Reprod Biol. 2001; 94(1):69-72. DOI: 10.1016/s0301-2115(00)00321-3. View