Measuring Activated Clotting Time During Cardiac Catheterization and PCI: The Effect of the Sampling Site

Overview

Journal J Interv Cardiol

Publisher Wiley

Specialty Cardiology & Vascular Diseases

Date 2021 Oct 8

PMID 34621140

Authors

J C Heemelaar

T Berkhout

A A C M Heestermans

J C Zant

A M J de Vos

N J W Verouden

M T Dirksen

J van Ramshorst

Affiliations

Soon will be listed here.

Abstract

Results: In 100 patients (mean age 67.1, 65% male), no significant differences were observed in ACT values obtained from the guiding catheter and arterial sheath (mean difference (MD) -18.3 s; standard deviation (SD) 96 s; =0.067). Contrarily, ACT values obtained from the intravenous line were significantly lower as compared to values obtained from the guiding catheter (MD 25.7 s; SD 75.5; =0.003) and arterial sheath (MD 39 s; SD 102.8; < 0.001). Furthermore, ACT measurements from the arterial sheath showed a statistically significant proportional bias when compared to the other sampling sites (sheath vs. catheter, = 0.761, =0.001; sheath vs. IVL, = 1.013, < 0.001).

Conclusions: The present study shows statistical significance and possibly clinically relevant variations between ACT measurements from different sample sites. Bias in ACT measurements may be minimized by using uniform protocols for ACT measurement during cardiac catheterization.

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