Cellular Pathways Influenced by Protein Arginine Methylation: Implications for Cancer

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2021 Oct 7

PMID 34619091

Citations 56

Authors

Jian Xu

Stephane Richard

Affiliations

Soon will be listed here.

Abstract

Arginine methylation is an influential post-translational modification occurring on histones, RNA binding proteins, and many other cellular proteins, affecting their function by altering their protein-protein and protein-nucleic acid interactions. Recently, a wealth of information has been gathered, implicating protein arginine methyltransferases (PRMTs), enzymes that deposit arginine methylation, in transcription, pre-mRNA splicing, DNA damage signaling, and immune signaling with major implications for cancer therapy, especially immunotherapy. This review summarizes this recent progress and the current state of PRMT inhibitors, some in clinical trials, as promising drug targets for cancer.

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